Ethnopharmacology and Neurodegenerative Disorders

Abstract

Neurodegenerative disorders, exemplified by Alzheimer's and Parkinson's diseases, significantly affect both individuals and healthcare systems. Despite continuous research endeavors, there are no definitive cures for these conditions, and existing treatments merely alleviate symptoms. An intriguing avenue for investigation is ethnopharmacology, a field that draws inspiration from traditional healing practices across the globe to identify natural compounds potentially capable of protecting neurons. These substances, derived from plants and other origins, offer potential advantages like antioxidative and anti-inflammatory properties. Nevertheless, they necessitate rigorous examination and confirmation of their safety and effectiveness. Natural products possess varied chemical structures, enabling them to interact with diverse molecular targets involved in the functioning and preservation of neurons, whereas synthetic drugs provide specificity and potency. The selection between these approaches depends on their respective merits and drawbacks, warranting thorough assessment within the context of neurodegenerative disorders. This review provides an overview of current and future trends in ethnopharmacology, as well as the exploration of natural products and synthetic drugs for these conditions, emphasizing the potential benefits and challenges, and underscoring the importance of a well-balanced research approach and integration in the quest for effective treatments.