Evaluating the possibility that drug-induced arrhythmia may interfere with cardiovascular complications caused by the Covid 19 virus.
DOI:
https://doi.org/10.22034/LSSJ.2024.96Abstract
Objective: Cardiac arrhythmias are one of the main causes of morbidity and mortality in the world, but the underlying mechanisms are still not well defined. In the last decade, it has been shown that inflammation causes a wide variety of arrhythmias. It becomes specific for atrial arrhythmia (fibrillation, long QT syndrome, tachycardia and atrial blocks. In addition, it seems that inflammatory cytokines play a role in cardiac ascites and the development of arrhythmia. The aim of this study is evaluation of patients with covid-19 disease who also had arrhythmia and the assay of inflammatory and laboratory factors in them and also arrhythmogenic drugs interaction.
Methods: 140 patients with covid-19 were selected. Cardiac arrhythmia was diagnosed in 70 patients by using ECG images. The variables of blood and inflammatory factors, and the use of drugs were determined in two groups of covid-19 patients with arrhythmia and those without. Also, the values of QT interval and heart rate were extracted from their EKG and compared by T-TEST analysis. Lab parameters were prepared by the laboratory documentation center and evaluated in groups with and without arrhythmia, as well as in deceased patients.
Results: The results showed that patients with covid-19 who have arrhythmia have longer QT values than covid-19 patients without arrhythmia. But the heart rate (HR) in these two groups was not different, in other words, HR is relatively high in both groups. Also, all the blood factors and especially the predictive factor of lymphocyte to neutrophil ratio are significantly high in these patients. Also, the inflammatory factors as ESR, CRP, in these patients are significantly P<0.001 more than those of covid-19 patients without arrhythmia. A higher percentage of patients who died and had arrhythmia used azithromycin and hydroxychloroquine alone and together.
Keywords: Covid-19, Arrhythmia, Inflammation, Hydroxychloroquine, Azithromycin
