In Vivo and In Vitro Models of Pancreatic Cancer: A Comparative Study

Authors

  • Nazanin Jamshidi Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran , Tehran, Iran
  • Aniya Ghasemzadeh Department of Biology, Parand Branch, Islamic Azad University, Parand, Iran
  • Negar Jamshidi Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran , Tehran, Iran
  • Vahid Chaleshi Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran , Tehran, Iran

DOI:

https://doi.org/10.22034/LSSJ.2023.1.60

Keywords:

Pancreatic ductal adenocarcinoma, in vitro models ,in vivo models

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer and has an extremely low 5-year survival rate of less than 10%, making it one of the deadliest solid tumors. To improve our understanding of the genesis and progression of this devastating disease, novel laboratory approaches have been developed. In this review, we provide a comprehensive summary of the current in vitro and in vivo models of PDAC, including established murine and human PDAC cell lines, organoids, and genetically engineered models. In addition, we compare these models and analyze published in vitro and in vivo PDAC models to elucidate the molecular basis of pancreatic carcinogenesis.

 

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Published

2023-05-10

How to Cite

Jamshidi, N., Ghasemzadeh, A., Jamshidi, N., & Chaleshi, V. (2023). In Vivo and In Vitro Models of Pancreatic Cancer: A Comparative Study. Life Sciences Student Journal, 1(1), 40–55. https://doi.org/10.22034/LSSJ.2023.1.60

Issue

Vol. 1 No. 1 (2023)

Section

Articles