Low-level laser therapy synergistically improves the effects of natural killer cell-mediated immunotherapy in cancer

Abstract

Abstract

Different kinds of treatments have been developed to fight cancers. The types of treatments that patients receive will be dependent on the cancer type and how advanced it is. Some patients are treated with only one way, but most patients receive combination therapies, such as surgery followed by chemotherapy, immunotherapy and/or radiation therapy. low-level laser therapy (LLLT), also known as photobiomodulation (PBM) therapy, is a low-power monochromatic and coherent light that has been used successfully for healing injuries and combat malignancies. Immune cell therapy is a promising approach that is applied to fight cancers using cellular immune system. In this regard, natural killer (NK) cells belonging to innate immunity are widely used to kill cancer cells. In this article, we hypothesize to explain how PBM therapy can enforce the effect of NK cell-mediated immunotherapy on cancers.