Nano silver effects on developing airway: a histological evaluation

Abstract

Introduction: Nano silver is widely used for its antibacterial effect. Nanoparticles have toxicity effects in the environment. People who are at risk of nanomaterials may have the effect of nanoparticles on the environment and also they will be discharged due to toxic environmental contamination. The nanoparticles may have altered the immune system and blood cells and improper use of them is harmful to the body. Silver nanoparticles can enter the bloodstream and then spread in the placenta, therefore also affecting the development of organs.
Methods: Pregnant Wister rats were administrated with concentrations of 125, 750, and 1500 mg/kg/day silver colloid nanoparticles via gavage in and histologically evaluated the airway development at the nineteenth day of gestation.
Result: Our finding reveals that a noted delay in lung embryonic development occurred in all three concentrations 125,750 and 1500 mg/kg/day.
Conclusion: In this study, possible teratogenic effects of silver nanoparticles appear in different stages of rat lung embryogenesis.