Food‑Derived Probiotics and Breast Cancer: A Narrative Review of Mechanisms, Clinical Evidence, and Practical Considerations (2020–2025)
Food-Derived Probiotics & Breast Cancer (2020–2025): Mechanisms, Evidence, Practice
DOI:
https://doi.org/10.22034/LSSJ.2025.165Abstract
Background: Evidence linking food‑derived probiotics to supportive care in breast cancer has grown quickly. We reviewed recent mechanisms (immune, barrier, estrogen metabolism) and human data.
Methods: Narrative search of 2020–2025 literature on probiotics/fermented foods and BC outcomes.
Results: Early trials suggest benefits for GI tolerance, weight/metabolic control, lymphedema volume, and quality‑of‑life during therapy. Mechanistic work highlights SCFAs, bile‑salt hydrolase and microbial crosstalk with apoptotic pathways.
Conclusions: Probiotics and fermented foods are promising adjuncts for BC supportive care. Larger, standardized RCTs with safety surveillance are needed.
Keywords: breast cancer; probiotics; fermented foods; Lactobacillus; Bifidobacterium; microbiome; estrobolome; chemotherapy; synbiotics; postbiotics
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