Effective treatment of GIST metastasis by electrochemotherapy with high frequency and low voltage: Case report study

Abstract

Electrochemotherapy (ECT) involves the use of electrical pulses to enhance the uptake of chemotherapy drugs such as bleomycin and cisplatin in solid and surface tumor cells, which has become a valuable treatment option in oncology. Which is not only useful as a palliative treatment but also a safe treatment approach. This method guarantees the best possible results in the minimum number of sessions and reduces complications. During this method, fewer chemotherapy drugs are used and the patient experiences muscle contractions due to high amplitude and low repetitions. Electrochemotherapy with high frequency and low voltage (LVHF) has been developed and optimized in vitro and in vivo and can be used in the clinic. In the present study, a case of Gist metastasis in the abdomen is reported. In this case, LVHF ECT was used to reduce the size and relieve the pain and symptoms of metastasis to the abdominal region in clinical conditions. Our electrochemotherapy method shows good clinical results and according to World Health Organization (WHO) standards, the tumor responded partially to the treatment. However, further studies on this new method are necessary to prove that LVHF ECT can be considered a standard treatment method.