The effect of intermittent fasting diet on breast tumor growth rate in animal models

Authors

  • Mohammad Parsa Khalaj Students’ Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran
  • Farideh Bahrami Department of Physiology and Medical Physics, School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
  • Zohreh Jangravi Department of Biochemistry, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Mojtaba Sepandi Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
  • Zeinab Shankayi Department of Physiology and Medical Physics, School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran

DOI:

https://doi.org/10.22034/LSSJ.2025.132

Abstract

Intermittent fasting (IF) is effective lifestyle interventions with powerful anti-carcinogenic actions. Whereas, the Breast cancer (BC) is the most-frequent malignancy amongst women, the effects of IF on breast cancer growth rate is unclear. The purpose of the current study was to investigate the effect of IF on volume changing of breast cancer in animal model.

The mice with 4T1 tumor cells were divided in two groups, first group as a control and second intermittent fasting diet  until the tumor size reached about 5(mm )*5(mm). This time is calculated and after that the volume of tumors for 15 days measured.

IF demonstrated significant inhibition of tumor growth. Also, in our study observed that in purebred female Bulb/c mice injected with 4T1 cancer cells, the cancer tumors in the group that experienced intermittent fasting diet reached the desire size, later.

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Published

2025-02-15

How to Cite

Khalaj, M. P., Bahrami, F. ., Jangravi, Z. ., Sepandi, M., & Shankayi, Z. . (2025). The effect of intermittent fasting diet on breast tumor growth rate in animal models. Life Sciences Student Journal, 3(1), 33–37. https://doi.org/10.22034/LSSJ.2025.132

Issue

Vol. 3 No. 1 (2025): Vol.3 No.1 (2025)

Section

Articles

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