Nephroprotective effect of biocurcumin and phyllanthus emblica in cisplatin-induced renal injury in rats

Authors

  • Ankita Department of Pharmacology Maulana Azad Medical College, New Delhi-110002
  • Dr Bhupinder Singh Kalra Department of Pharmacology Maulana Azad Medical College, New Delhi-110002
  • Akhilesh Mishra Department of Pharmacology Maulana Azad Medical College, New Delhi-110002
  • Shramana Mandal Department of Pathology Maulana Azad Medical College, New Delhi-110002
  • Shalini Chawla Department of Pharmacology Maulana Azad Medical College, New Delhi-110002

DOI:

https://doi.org/10.22034/LSSJ.2024.128

Abstract

Background- Cisplatin is the most commonly used anticancer agent in treating many tumours. It has been postulated that oxidative stress is responsible for cisplatin-induced nephrotoxicity. The present study aimed to evaluate the reno-protective effects of Biocurcumin and Phyllanthus emblica in cisplatin-induced renal injury in rats.

Methods-The study was conducted in SD rats for 7 days. Total of 35 rats were divided into 5 groups. Group I received normal Saline throughout the study. Group II received a single dose of cisplatin on the 4th day (20mg/kg). Group III, group IV and group V received bio-curcumin (100 mg/kg), phyllanthus emblica (300mg/kg) and a combination of both plant extract orally for 7 days and a single dose of cisplatin on 4th day. Rats were euthanized with an overdose of thiopental sodium, blood and tissue samples were collected for assessment on the 8th day. Renal injury was assessed by serum creatinine and BUN. SOD and catalase were assessed by ELISA in renal tissue. The degree of severity of renal tissue was assessed by histopathology. 

Results- It was observed that biocurcumin and phyllanthus emblica extracts significantly (p<0.05) attenuate renal damage by decreasing serum creatinine and BUN. It significantly enhances the activities of catalase and SOD—a single dose of cisplatin results in marked inflammation, protein cast, and cellular swelling. But, in groups treated with plant extract along with cisplatin above histopathological changes were not observed.  

Conclusion- concluded that plant extracts ameliorate renal damage caused by cisplatin may be due to its antioxidative properties.

Keywords- Biocurcumin, Phyllanthus emblica, Cisplatin, Catalase, BUN, SOD.

Downloads

Published

2024-12-30

How to Cite

Ankita, Dr Bhupinder Singh Kalra, Akhilesh Mishra, Shramana Mandal, & Shalini Chawla. (2024). Nephroprotective effect of biocurcumin and phyllanthus emblica in cisplatin-induced renal injury in rats . Life Sciences Student Journal, 2(3). https://doi.org/10.22034/LSSJ.2024.128

Issue

Vol. 2 No. 3 (2024): Vol.2No.3 (2024)

Section

Articles

License

 Publisher's Own License

This work is licensed under the publisher's own license, which allows for sharing and use under specific conditions. Attribution is required; users must give appropriate credit to the original creator. Additionally, this license includes a No Commercial Usage clause, meaning that the work cannot be used for commercial purposes or for profit. Users are encouraged to share and adapt the content non-commercially, provided they adhere to these guidelines. Please ensure that you respect the terms of this license to promote a collaborative and respectful use of the work.