The Role of Probiotics in Treatment of Helicobacter pylori Infections

Abstract

The term "probiotics" refers to organisms that, when administered in sufficient quantities, confer health benefits on the host and have a variety of effects, including inhibition of pathogens, stimulation of organ function, and activation of the immune response in the human body. Studies have demonstrated that probiotics can inhibit Helicobacter pylori in both experimental and clinical settings. Competition for nutrients, production of bactericidal substances, competition to inhibit adherence and stimulation of host functions, and immunity are the mechanisms by which probiotics reduce H. pylori infections. In addition, probiotics are used clinically to eradicate H. pylori infection, and the effects of probiotics as a single therapy and in combination with other drugs, including proton pump inhibitors and anti-H. Pylori antibiotics have been reported. Studies have shown that probiotics are increasing the eradication rate and preventing side effects such as diarrhea, nausea, vomiting, or a taste disorder. Some probiotics may be helpful for the eradication of H. pylori and their efficacy in reducing side effects of treatment with antibiotics, but more research is necessary to answer several questions relating to the mechanism of action of Probiotics. Moreover, in future studies, it is necessary to clarify the strain specificity, dose, and duration of probiotic therapy for eradication of H. pylori infection.