The Power of Daphnetin: Enhancing Nrf2 Signaling Pathway

Abstract

Chronic inflammation and oxidative stress are involved in a range of diseases. The Nrf2 pathway is crucial in controlling cellular defenses against stresses. Daphnetin (DAP), a compound derived from plants such as Daphne odora, has shown promise to activate Nrf2, a protein with potential therapeutic uses. This review examines how DAP influences the Nrf2 pathway, increasing genes that promote antioxidant and anti-inflammatory effects. We present preclinical evidence showcasing the effectiveness of DAP in several illness models linked to inflammation and oxidative stress. In addition, we investigate recent progress in altering the structure of DAP to increase its effectiveness and improve its pharmacological characteristics. Lastly, we address prospective areas of future study, highlighting the importance of clinical translation studies in fully realizing DAP's therapeutic benefits. In summary, this study highlights the potential of DAP as a natural Nrf2 activator, which has important implications for preventing and managing diseases.