The Journal of Applied Tissue Engineering

Evolving Trends in Bioactive Glass Coatings: A Systematic Review of Global Research and Applications

Mon, 20 Oct 2025 00:00:00 +0000

Bioactive glass (BG) coatings are essential in advancing regenerative medicine, enhancing interactions with biological tissues and improving the performance of medical and dental implants. Since their discovery in the late 1960s, BGs have evolved to meet the demands of biomedical applications, particularly in orthopedics and dentistry. This systematic review examines the development and recent advancements in BG coatings, focusing on innovative techniques that address mechanical and biological challenges. Utilizing VOSviewer software, the review conducts a bibliometric analysis to map research networks and identify influential studies shaping BG technology. It highlights promising research directions, emphasizing nanotechnology and composite materials. These innovations aim to overcome existing limitations of BGs, unlocking new possibilities for bone regeneration and other therapeutic areas. The review underscores significant progress in BG coatings and points to future breakthroughs that could redefine their role in modern medicine, making them vital for next-generation medical treatments.

Genetically Engineered Cell Therapies, The Next Frontier in Regenerative Medicine

Melina Rajabi — Sat, 07 Jun 2025 00:00:00 +0000

Genetically engineered cell therapies (GECTs) represent a significant milestone in regenerative medicine that entails the application of living cells in conjunction with genetic modification to treat or prevent an extensive range of disease at their etiological axis. Cell and gene therapies are included in this category, and these have been of particular interest for the management of complex and otherwise refractory diseases such as cancer and inherited genetic disorders. One of the greatest achievements in the field was the 2017 FDA's approval of Kymriah, a CAR-T cell therapy for pediatric leukemia, that ushered the doors to a new age of personalized medicine. Development of GECTs has progressed since then with the emergence of gene-editing technologies such as CRISPR, which allow more precise and effective interventions.

While therapeutic applicability is enormous, emergence of GECTs also presents important challenges. Areas of greatest contention involve ethical concerns about informed consent, long-term safety, and the possibility of unanticipated genetic consequences. Further, the cost of such therapy’s limits availability to many, raising essential questions about healthcare equity and best methods of public versus private funding to distribute these services widely.

Regulatory bodies such as the U.S. Food and Drug Administration are also changing their infrastructure to better accommodate these new treatments, attempting to balance safety with innovation. With all involved in the healthcare environment collaborating to address these issues, the science is moving very quickly.

Collectively, GECTs hold game-changing promise to redefine disease treatment and improve patient care, at the forefront of medicine's future. Additional innovation and equitable use will be essential to realizing their full promise.

Management of Iatrogenic Internal Root Resorption: A Case Report

Arezou liaghat, seyede aye shekarbaghani, Zohreh Khalilak — Sun, 24 Aug 2025 00:00:00 +0000

Aim : To report the treatment and follow-up of a mandibular first premolar with internal resorption managed by root canal treatment & cold ceramic repair.

Summary: This study presents a case of extensive internal root resorption affecting tooth 34 (FDI) in a 63-year-old male patient, without a history of trauma in that region. Despite a guarded prognosis but encouraged by a healthy periodontal condition, treatment based on reconstructing the tooth with cold ceramic and composite restoration was carried out. Follow-up radiographs over 12 months demonstrated the maintenance of a functional tooth.

a report of a successful endodontic treatment of a taurodontism tooth with pulp stones in the pulp chamber: case report

Mohammad Gharishvandi Abraki, seyede aye shekarbaghani — Mon, 09 Jun 2025 00:00:00 +0000

Introduction: Taurodontism is a rare dental developmental disorder characterized by an elongated pulp chamber and displaced furcation site, with a prevalence of 0.5-2.5%. The disorder can appear as a separate anomaly or as part of a syndrome, and its clinical appearance is similar to that of normal teeth. Case report: In this study, we report a rare case of taurodontism with pulp stones in a patient's right mandibular first molar. Despite the challenges of treating this dental anomaly, successful root treatment was achieved. Conclusion: Despite the challenges posed by taurodontism and pulp stones, successful root treatment can be achieved with careful planning and execution. Our case report highlights the importance of careful diagnosis and treatment of this rare dental anomaly. It serves as a valuable example for clinicians encountering similar cases.