A Review of 50 Herbs for Wound Healing: Traditional Use and Modern Evidence
DOI:
https://doi.org/10.22034/JATE.2023.88Abstract
Herbal medicine is the use of plants or plant-based substances to treat various health conditions, including wounds. Wounds are injuries that damage the skin or other body tissues. Wound healing is a complex process that involves four phases: hemostasis, inflammation, proliferation, and remodeling. Herbal medicine can enhance wound healing by providing anti-inflammatory, antimicrobial, antioxidant, and analgesic effects. Herbal medicine can also stimulate cellular regeneration and collagen production, which are essential for tissue repair. In this review, we introduce 50 herbs that have been reported to be effective for wound healing. These plants have a long history of use based on experience, but they have also been confirmed to be effective in wound healing by modern medical methods. However, herbal medicine should not replace conventional medical care for severe wounds. These plants can be a good source for researchers to design and make more effective drugs with less side effects for wound healing.
References
References:
Sajad Lotfi, Hamid Gholizadeh, Alireza Naqinezhad, Mahdieh Amirzadeh, Seyed Javad Davarpanah. An ethnobotanical survey of medicinal plants of Rudsar and Amlash province. Journal of Applied plant biology . 2003;1(1):1–11.
Boy HIA, Rutilla AJH, Santos KA, Ty AMT, Yu AI, Mahboob T, et al. Recommended Medicinal Plants as Source of Natural Products: A Review. Digital Chinese Medicine. 2018 Jun;1(2):131–42.
Xu Z, Dong M, Yin S, Dong J, Zhang M, Tian R, et al. Why traditional herbal medicine promotes wound healing: Research from immune response, wound microbiome to controlled delivery. Adv Drug Deliv Rev. 2023 Apr;195:114764.
Hosseinkhani A, Falahatzadeh M, Raoofi E, Zarshenas MM. An Evidence-Based Review on Wound Healing Herbal Remedies From Reports of Traditional Persian Medicine. J Evid Based Complementary Altern Med. 2017 Apr 22;22(2):334–43.
Fana SE, Ahmadpour F, Rasouli HR, Tehrani SS, Maniati M. The effects of natural compounds on wound healing in Iranian traditional medicine: A comprehensive review. Complement Ther Clin Pract. 2021 Feb;42:101275.
Xu Z, Dong M, Yin S, Dong J, Zhang M, Tian R, et al. Why traditional herbal medicine promotes wound healing: Research from immune response, wound microbiome to controlled delivery. Adv Drug Deliv Rev. 2023 Apr;195:114764.
Olisova OY, Snarskaya ES, Gladko V V., Burova EP. Russian traditional medicine in dermatology. Clin Dermatol. 2018 May;36(3):325–37.
Anand U, Tudu CK, Nandy S, Sunita K, Tripathi V, Loake GJ, et al. Ethnodermatological use of medicinal plants in India: From ayurvedic formulations to clinical perspectives – A review. J Ethnopharmacol. 2022 Feb;284:114744.
Chattopadhyay K, Panniyammakal J, Biswas TK, Heinrich M, Lewis SA, Greenfield SM, et al. Effectiveness and safety of ayurvedic medicines in type 2 diabetes mellitus management: A systematic review protocol. JBI Evid Synth. 2020;18(11).
Akbik D, Ghadiri M, Chrzanowski W, Rohanizadeh R. Curcumin as a wound healing agent. Life Sci. 2014 Oct;116(1):1–7.
Meng FC, Zhou YQ, Ren D, Wang R, Wang C, Lin LG, et al. Turmeric: A Review of Its Chemical Composition, Quality Control, Bioactivity, and Pharmaceutical Application. In: Natural and Artificial Flavoring Agents and Food Dyes. Elsevier; 2018. p. 299–350.
Bagchi A. Extraction of Curcumin. IOSR J Environ Sci Toxicol Food Technol. 2012;1(3):01–16.
Ahmad RS, Hussain MB, Sultan MT, Arshad MS, Waheed M, Shariati MA, et al. Biochemistry, Safety, Pharmacological Activities, and Clinical Applications of Turmeric: A Mechanistic Review. Evidence-Based Complementary and Alternative Medicine. 2020 May 11;2020:1–14.
Kulac M, Aktas C, Tulubas F, Uygur R, Kanter M, Erboga M, et al. The effects of topical treatment with curcumin on burn wound healing in rats. J Mol Histol. 2013 Feb 2;44(1):83–90.
Mohanty C, Das M, Sahoo SK. Sustained Wound Healing Activity of Curcumin Loaded Oleic Acid Based Polymeric Bandage in a Rat Model. Mol Pharm. 2012 Oct 1;9(10):2801–16. Liang G, Yang S, Zhou H, Shao L, Huang K, Xiao J, et al. Synthesis, crystal structure and anti-inflammatory properties of curcumin analogues. Eur J Med Chem. 2009 Feb;44(2):915–9.
Mun SH, Joung DK, Kim YS, Kang OH, Kim SB, Seo YS, et al. Synergistic antibacterial effect of curcumin against methicillin-resistant Staphylococcus aureus. Phytomedicine. 2013 Jun;20(8–9):714–8.
Singh RK, Rai D, Yadav D, Bhargava A, Balzarini J, De Clercq E. Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid. Eur J Med Chem. 2010 Mar;45(3):1078–86.
Ak T, Gülçin İ. Antioxidant and radical scavenging properties of curcumin. Chem Biol Interact. 2008 Jul;174(1):27–37.
Meng B, Li J, Cao H. Antioxidant and antiinflammatory activities of curcumin on diabetes mellitus and its complications. Curr Pharm Des. 2013;19(11):2101–13.
JOE B, VIJAYKUMAR M, LOKESH BR. Biological Properties of Curcumin-Cellular and Molecular Mechanisms of Action. Crit Rev Food Sci Nutr. 2004 Mar;44(2):97–111.
Sidhu GS, Singh AK, Thaloor D, Banaudha KK, Patnaik GK, Srimal RC, et al. Enhancement of wound healing by curcumin in animals. Wound Repair and Regeneration. 1998 Mar;6(2):167–77.
Thangapazham RL, Sharad S, Maheshwari RK. Skin regenerative potentials of curcumin. BioFactors. 2013 Jan 11;39(1):141–9.
Rezaei M, Oryan S, Nourani MR, Mofid M, Mozafari M. Curcumin nanoparticle-incorporated collagen/chitosan scaffolds for enhanced wound healing. Bioinspired, Biomimetic and Nanobiomaterials. 2018 Sep 1;7(3):159–66.
Mehrabani D, Farjam M, Geramizadeh B, Tanideh N, Amini M, Panjehshahin MR. The healing effect of curcumin on burn wounds in rat. World J Plast Surg. 2015 Jan;4(1):29–35.
Phan TT, See P, Lee ST, Chan SY. Protective Effects of Curcumin against Oxidative Damage on Skin Cells In Vitro: Its Implication for Wound Healing. The Journal of Trauma: Injury, Infection, and Critical Care. 2001 Nov;51(5):927–31.
S. Purohit, R. Solanki, V. Mathur, M. Mathur. Evaluation of wound healing activity of ethanolic extract of Curcuma longa rhizomes in male albino rats, . Asian J Pharmaceut Res. 2013;3(2):79–81.
Adepoju FO, Duru KC, Li E, Kovaleva EG, Tsurkan M V. Pharmacological Potential of Betulin as a Multitarget Compound. Biomolecules. 2023 Jul 12;13(7).
Ebeling S, Naumann K, Pollok S, Wardecki T, Vidal-y-Sy S, Nascimento JM, et al. From a Traditional Medicinal Plant to a Rational Drug: Understanding the Clinically Proven Wound Healing Efficacy of Birch Bark Extract. PLoS One. 2014 Jan 22;9(1):e86147.
Metelmann HR, Brandner JM, Schumann H, Bross F, Fimmers R, BFttger K, et al. Accelerated Reepithelialization by Triterpenes: Proof of Concept in the Healing of Surgical Skin Lesions. Skin Pharmacol Physiol. 2015;28(1):1–11.
Barret JP, Podmelle F, Lipový B, Rennekampff HO, Schumann H, Schwieger-Briel A, et al. Accelerated re-epithelialization of partial-thickness skin wounds by a topical betulin gel: Results of a randomized phase III clinical trials program. Burns. 2017 Sep;43(6):1284–94.
Frew Q, Rennekampff HO, Dziewulski P, Moiemen N, Zahn T, Hartmann B. Betulin wound gel accelerated healing of superficial partial thickness burns: Results of a randomized, intra‐individually controlled, phase III trial with 12‐months follow‐up. Burns. 2019 Jun;45(4):876–90.
Scheffler A. The Wound Healing Properties of Betulin from Birch Bark from Bench to Bedside. Planta Med. 2019 May 11;85(07):524–7.
Hoffmann J, Gendrisch F, Schempp CM, Wölfle U. New Herbal Biomedicines for the Topical Treatment of Dermatological Disorders. Biomedicines. 2020 Feb 8;8(2):27.
V.A. Solovieva. Traditional Methods of Health Promotion. St. Petersburg, Russia: Neva Publishing House,; 2005. 352 p.
Dorrigiv M, Zareiyan A, Hosseinzadeh H. Onion (Allium cepa) and its Main Constituents as Antidotes or Protective Agents against Natural or Chemical Toxicities: A Comprehensive Review. Iran J Pharm Res. 2021;20(1):3–26.
Fang QQ, Chen CY, Zhang MX, Huang CL, Wang XW, Xu JH, et al. The Effectiveness of Topical Anti-scarring Agents and a Novel Combined Process on Cutaneous Scar Management. Curr Pharm Des. 2017 Jun 16;23(15).
Draelos ZD. The ability of onion extract gel to improve the cosmetic appearance of postsurgical scars. J Cosmet Dermatol. 2008 Jun;7(2):101–4.
BERGSSON G, ARNFINNSSON J, STEINGRIMSSON O, THORMAR H. Killing of Gram-positive cocci by fatty acids and monoglyceridesNote. APMIS. 2001 Oct;109(10):670–8.
Chadeganipour M, Haims A. Antifungal activities of pelargonic and capric acid on Microsporum gypseum. Mycoses. 2001 Apr 16;44(3–4):109–12.
Durgaprasad S, Srivastava P. Burn wound healing property of Cocos nucifera : An appraisal. Indian J Pharmacol. 2008;40(4):144.
Zakaria ZA, Reezal I, Jais AMM, Somchit MN, Sulaiman MR, Marmin AHI, et al. The Anti-inflammatory, Anti-pyretic and Wound Healing Activities of Cocos nucifera (MATAG Types) Fresh Juice and Kernel Extract in Experimental Animals. Journal of Pharmacology and Toxicology. 2006 Oct 15;1(6):516–26.
CHAKRABORTY M, MITRA A. The antioxidant and antimicrobial properties of the methanolic extract from Cocos nucifera mesocarp. Food Chem. 2008 Apr 1;107(3):994–9.
Islam WU, Khan F, Waqas M, Ullah S, Halim SA, Rehman NU, et al. In-vivo anti-diabetic and anti-hyperlipidemic effects of natural metabolites from resin of Commiphora mukul and their in-silico to in-vitro target fishing. Biomedicine & Pharmacotherapy. 2023 Sep 1;165:115214.
Francis J, Raja S, Nair M. Bioactive Terpenoids and Guggulusteroids fromCommiphora mukul Gum Resin of Potential Anti-Inflammatory Interest. Chem Biodivers. 2004 Nov;1(11):1842–53.
Asif Saeed M. Antibacterial activities of some constituents from oleo-gum-resin of Commiphora mukul. Fitoterapia. 2004 Mar;75(2):204–8.
Al-Mobeeriek A. Effects of myrrh on intra-oral mucosal wounds compared with tetracycline- and chlorhexidine-based mouthwashes. Clin Cosmet Investig Dent. 2011 Aug;53.
Mirzaee F, Hosseini A, Jouybari HB, Davoodi A, Azadbakht M. Medicinal, biological and phytochemical properties of Gentiana species. J Tradit Complement Med. 2017 Oct;7(4):400–8.
Mathew A, Taranalli AD, Torgal SS. Evaluation of Anti-inflammatory and Wound Healing Activity of Gentiana lutea Rhizome Extracts in Animals. Pharm Biol. 2004 Jan 3;42(1):8–12.
Jillian Levy C. Gentian Root: The Ancient Herb that Aids Digestion, Wound Healing & More. 2018.
Yin C, Xie L, Guo Y. Phytochemical analysis and antibacterial activity of Gentiana macrophylla extract against bacteria isolated from burn wound infections. Microb Pathog. 2018 Jan;114:25–8.
Mathew A, Taranalli AD, Torgal SS. Evaluation of Anti-inflammatory and Wound Healing Activity of Gentiana lutea Rhizome Extracts in Animals. Pharm Biol. 2004 Jan 3;42(1):8–12.
Daneshvar-Ghahfarokhi S, Mohammadi-Shahrokhi V, Rahnama A, Nosratabadi R. Teucrium polium Extract Alleviates Pathological Features of Asthma via lL-12 and IFN-γ Modulation in Murine OVA-induced Allergic Asthma. Iran J Allergy Asthma Immunol. 2023 Sep 10;
Guesmi F, Saidi I, Abbassi R, Saidani M, Hfaiedh N, Landoulsi A. Therapeutic potential of second degree’s skin burns by topical dressing of Teucrium ramosissimum that promotes re‐epithelialization. Dermatol Ther. 2022 May 14;35(5).
Sharifi-Rad M, Pohl P, Epifano F, Zengin G, Jaradat N, Messaoudi M. Teucrium polium (L.): Phytochemical Screening and Biological Activities at Different Phenological Stages. Molecules. 2022 Feb 25;27(5):1561.
Gharaboghaz MN zadeh, Farahpour MR, Saghaie S. Topical co-administration of Teucrium polium hydroethanolic extract and Aloe vera gel triggered wound healing by accelerating cell proliferation in diabetic mouse model. Biomedicine & Pharmacotherapy. 2020 Jul;127:110189.
Ansari R SNNARMSHRKM. Ameliorative property of Teucrium polium on second degree burn. . J Herbmed Pharmacol . 2013;2:9–11.
Tariq M, Ageel AM, al-Yahya MA, Mossa JS, al-Said MS. Anti-inflammatory activity of Teucrium polium. Int J Tissue React. 1989;11(4):185–8.
Darabpour E, Motamedi H, Nejad SMS. Antimicrobial properties of Teucrium polium against some clinical pathogens. Asian Pac J Trop Med. 2010 Feb;3(2):124–7.
Batool Hashemibeni, Maryam Aliakbari, Mohammad Bakhtiari, Mohammad Kazemi, Mohsen Setayeshmehr. The effect of herbal components, pomegranate and icariin on the chondrogenesis of stem cells in the fibrin- micromass hydrogel system. THE JOURNAL OF APPLIED TISSUE ENGINEERING. 2023;9(1):18–30.
Singh J, Kaur HP, Verma A, Chahal AS, Jajoria K, Rasane P, et al. Pomegranate Peel Phytochemistry, Pharmacological Properties, Methods of Extraction, and Its Application: A Comprehensive Review. ACS Omega. 2023 Oct 3;8(39):35452–69.
Shinde V, Shende A., Mahadik K. Evaluation of antioxidant and wound healing potential of pomegranate peel gel formulation. Int J Pharmacogn . 2020;7:23–8.
Yan H, Peng K jun, Wang Q lin, Gu Z yi, Lu Y qin, Zhao J, et al. Effect of pomegranate peel polyphenol gel on cutaneous wound healing in alloxan-induced diabetic rats. Chin Med J (Engl). 2013;126(9):1700–6.
Ismail T, Sestili P, Akhtar S. Pomegranate peel and fruit extracts: A review of potential anti-inflammatory and anti-infective effects. J Ethnopharmacol. 2012 Sep;143(2):397–405.
Zubair M, Ekholm A, Nybom H, Renvert S, Widen C, Rumpunen K. Effects of Plantago major L. leaf extracts on oral epithelial cells in a scratch assay. J Ethnopharmacol. 2012 Jun;141(3):825–30.
Farid A, Sheibani M, Shojaii A, Noori M, Motevalian M. Evaluation of anti-inflammatory effects of leaf and seed extracts of Plantago major on acetic acid-induced ulcerative colitis in rats. J Ethnopharmacol. 2022 Nov 15;298:115595.
Keshavarzi A, Montaseri H, Akrami R, Moradi Sarvestani H, Khosravi F, Foolad S, et al. Therapeutic Efficacy of Great Plantain (Plantago major L.) in the Treatment of Second-Degree Burn Wounds: A Case-Control Study. Int J Clin Pract. 2022 Aug 1;2022:1–7.
Ghanadian M, Soltani R, Homayouni A, Khorvash F, Jouabadi SM, Abdollahzadeh M. The Effect of Plantago major Hydroalcoholic Extract on the Healing of Diabetic Foot and Pressure Ulcers: A Randomized Open-Label Controlled Clinical Trial. Int J Low Extrem Wounds. 2022 Jan 19;153473462110707.
Amini M, Kherad M, Mehrabani D, Azarpira N, Panjehshahin MR, Tanideh N. Effect of Plantago major on Burn Wound Healing in Rat. J Appl Anim Res. 2010 Mar;37(1):53–6.
Li M, Qiu W, Wang Q, Li N, Liu L, Wang X, et al. Nitric Oxide-Releasing Tryptophan-Based Poly(ester urea)s Electrospun Composite Nanofiber Mats with Antibacterial and Antibiofilm Activities for Infected Wound Healing. ACS Appl Mater Interfaces. 2022 Apr 13;14(14):15911–26.
Dehdari S, Hajimehdipoor H. Medicinal Properties of Adiantum capillus-veneris Linn. in Traditional Medicine and Modern Phytotherapy: A Review Article. Iran J Public Health. 2018 Feb;47(2):188–97.
Nilforoushzadeh MA, Javanmard SH, Ghanadian M, Asghari G, Jaffary F, Yakhdani AF, et al. The Effects of Adiantum capillus-veneris on Wound Healing: An Experimental In Vitro Evaluation. Int J Prev Med. 2014 Oct;5(10):1261–8.
Ishaq MS, Hussain MM, Siddique Afridi M, Ali G, Khattak M, Ahmad S, et al. In Vitro Phytochemical, Antibacterial, and Antifungal Activities of Leaf, Stem, and Root Extracts of Adiantum capillus veneris. The Scientific World Journal. 2014;2014:1–7.
Galehdari H, Negahdari S, Kesmati M, Rezaie A, Shariati G. Effect of the herbal mixture composed of Aloe Vera, Henna, Adiantum capillus-veneris, and Myrrha on wound healing in streptozotocin-induced diabetic rats. BMC Complement Altern Med. 2016 Oct 6;16(1):386.
Nilforoushzadeh MA, Javanmard SH, Ghanadian M, Asghari G, Jaffary F, Yakhdani AF, et al. The Effects of Adiantum capillus-veneris on Wound Healing: An Experimental In Vitro Evaluation. Int J Prev Med. 2014 Oct;5(10):1261–8.
Brown DB. Spider Bite Wound Care and Review of Traditional and Advanced Treatment Options. Federal Practitioner. 2023 Aug;40(8).
Eric Teplicki Qianli Ma David E.ad Juan Chen Jie Li, Castillo Mina Zarei Adam P. Hust. The Effects of Aloe vera on Wound Healing in Cell Proliferation, Migration, and Viability. Wounds 2018;30(9):263–268. 2018;30(9):293–268.
Adnan MJ AAHARHA. Study of the efficacy of Aloe vera extracts in treatment of non-infected 340 Journal of Evidence-Based Complementary & Alternative Medicine 22(2) wounds induced by sulferric acid and infected wounds with Staphylococcus aureus. Int J Adv Res . 2015;3:593–601.
Oryan A, Mohammadalipour A, Moshiri A, Tabandeh MR. Topical Application of Aloe vera Accelerated Wound Healing, Modeling, and Remodeling. Ann Plast Surg. 2016 Jul;77(1):37–46.
garry O OMBMC. garry O, Olaleye M, Bello-Michael C. Comparative antimicrobial activities of Aloe vera gel and leaf. . Afr J Biotechnol . 2005;4:1413–4.
Tabandeh MR, Oryan A, Mohammadalipour A. Polysaccharides of Aloe vera induce MMP-3 and TIMP-2 gene expression during the skin wound repair of rat. Int J Biol Macromol. 2014 Apr 1;65:424–30.
Noorgaldi S, Sarkala HB, Enayati A, Khori V, Zengin G, Jahanshahi M. Neuroprotective effect of Potentilla reptans L. root in the rat brain global ischemia/reperfusion model. Arch Pharm (Weinheim). 2023 Aug 29;
Tomovic MT, Cupara SM, Popovic-Milenkovic MT, Ljujic BT, Kostic MJ, Jankovic SM. Antioxidant and anti-inflammatory activity of Potentilla reptans L. Acta Pol Pharm. 2015;72(1):137–45.
Watkins F, Pendry B, Sanchez-Medina A, Corcoran O. Antimicrobial assays of three native British plants used in Anglo-Saxon medicine for wound healing formulations in 10th century England. J Ethnopharmacol. 2012 Nov;144(2):408–15.
Mirzaei H, Salehi A, Javan B, Enayati A, nabi MO, Zahedi M, et al. Potentilla reptans L. preconditioning regulates H19 and MIAT long noncoding RNAs in H9C2 myoblasts Ischemia/Reperfusion model. BMC Complement Med Ther. 2023 Jul 31;23(1):272.
Tobyn G, Denham A, Whitelegg M. Potentilla erecta, tormentil. Medical Herbs. 2011;241–52.
Kuo PC, Li YC, Wu TS. Chemical Constituents and Pharmacology of the Aristolochia (馬兜鈴 mădōu ling) species. J Tradit Complement Med. 2012 Oct;2(4):249–66.
Bhattacharjee P, Bhattacharyya D. Characterization of the aqueous extract of the root of Aristolochia indica: evaluation of its traditional use as an antidote for snake bites. J Ethnopharmacol. 2013 Jan 9;145(1):220–6.
Shirwaikar A, Somashekar AP, Udupa AL, Udupa SL, Somashekar S. Wound healing studies of Aristolochia bracteolata Lam. with supportive action of antioxidant enzymes. Phytomedicine. 2003 Jan;10(6–7):558–62.
Girija DM, Kalachaveedu M, Subbarayan R, Jenifer P, Rao SR. Aristolochia bracteolata Enhances Wound Healing in vitro through Anti-inflammatory and Proliferative Effect on Human Dermal Fibroblasts and Keratinocytes. Pharmacognosy Journal. 2017 Nov 25;9(6s):s129–36.
Iwu MM. Handbook of African medicinal plants. . 1st ed. Boca Raton:CRC Press; 1993. 123-4. p.
Burdock GA. Encyclopedia of food and color additives. 1st ed. Boca Raton:CRC Press; 1996. 2818-20. p.
Weiping W., Tragacanth, karaya. In, Phillips GO, Williams PA. Handbook of hydrocolloids. 1st ed. Boca Raton:CRC Press; 2000. 231-46. p.
Nazemi Z, Sahraro M, Janmohammadi M, Nourbakhsh MS, Savoji H. A review on tragacanth gum: A promising natural polysaccharide in drug delivery and cell therapy. Int J Biol Macromol. 2023 Jun;241:124343.
Azarniya A, Tamjid E, Eslahi N, Simchi A. Modification of bacterial cellulose/keratin nanofibrous mats by a tragacanth gum-conjugated hydrogel for wound healing. Int J Biol Macromol. 2019 Aug;134:280–9.
Gentry HS. Gum tragacanth in Iran. Econ Bot. 1957 Jan;11(1):40–63.
Fayazzadeh E, Rahimpour S, Ahmadi SM, Farzampour S, Anvari MS, Boroumand MA, et al. Acceleration of skin wound healing with Tragacanth (Astragalus) preparation: An experimental pilot study in rats. Acta Med Iran. 2014;52(1):3–8.
Baradaran Rahimi V, Rahmanian Devin P, Askari VR. Boswellia serrata inhibits LPS-induced cardiotoxicity in H9c2 cells: Investigating role of anti-inflammatory and antioxidant effects. Toxicon. 2023 Jun;229:107132.
Pengzong Z, Yuanmin L, Xiaoming X, Shang D, Wei X, Zhigang L, et al. Wound Healing Potential of the Standardized Extract of Boswellia serrata on Experimental Diabetic Foot Ulcer via Inhibition of Inflammatory, Angiogenetic and Apoptotic Markers. Planta Med. 2019 May 25;85(08):657–69.
Sferra R, Vetuschi A, Catitti V, Ammanniti S, Pompili S, Melideo D, et al. Boswellia serrata and Salvia miltiorrhiza extracts reduce DMN-induced hepatic fibrosis in mice by TGF-beta1 downregulation. Eur Rev Med Pharmacol Sci. 2012 Oct;16(11):1484–98.
Ammon H. Boswellic Acids in Chronic Inflammatory Diseases. Planta Med. 2006 Oct;72(12):1100–16.
Eyre H, Hills J, Watkins D. Compositions containing boswellia extracts. Quest International B.V. Patent US 6,589,516B1; 2003. Patent US 6,589,516B1, 2003.
Calzavara-Pinton P, Zane C, Facchinetti E, Capezzera R, Pedretti A. Topical Boswellic acids for treatment of photoaged skin. Dermatol Ther. 2010 Jan;23:S28–32.
Togni S, Maramaldi G, Bonetta A, Giacomelli L, Di Pierro F. Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial. Eur Rev Med Pharmacol Sci. 2015 Apr;19(8):1338–44.
Arunabha Mallik, Damodhar Goupale, Hemant Dhongade, Satish Nayak. Evaluation of Boswellia serrata oleo-gum resin for wound healing activity. Der Pharmacia Lettre . 2010;Vol.2:457–63.
Lee Y, Kim S, Yang B, Lim C, Kim JH, Kim H, et al. Anti-inflammatory effects of Brassica oleracea Var. capitata L. (Cabbage) methanol extract in mice with contact dermatitis. Pharmacogn Mag. 2018;14(54):174.
Sarandy MM, Novaes RD, da Matta SLP, Mezencio JM da S, da Silva MB, Zanuncio JC, et al. Ointment of Brassica oleracea var. capitata Matures the Extracellular Matrix in Skin Wounds of Wistar Rats. Evidence-Based Complementary and Alternative Medicine. 2015;2015:1–9.
Hassanzadeh G. Comparing effects of Silver sulfadiazine, Sucralfate and Brassica oleracea extract on burn wound healing. Life Sci J. 10:104.
SHAFEIE N, TABATABAI NAINI A, JAHROMI H. Comparison of different concentrations of calendula officinalis gel on cutaneous wound healing. Biomedical and Pharmacology Journal. 2015 Dec 28;8(2):979–92.
Villanueva-Bermejo D, Vázquez E, Villalva M, Santoyo S, Fornari T, Reglero G, et al. Simultaneous Supercritical Fluid Extraction of Heather (Calluna vulgaris L.) and Marigold (Calendula officinalis L.) and Anti-Inflammatory Activity of the Extracts. Applied Sciences. 2019 May 31;9(11):2245.
Kang CH, Rhie SJ, Kim YC. Antioxidant and Skin Anti-Aging Effects of Marigold Methanol Extract. Toxicol Res. 2018 Jan 15;34(1):31–9.
Pommier P, Gomez F, Sunyach MP, D’Hombres A, Carrie C, Montbarbon X. Phase III Randomized Trial of Calendula Officinalis Compared With Trolamine for the Prevention of Acute Dermatitis During Irradiation for Breast Cancer. Journal of Clinical Oncology. 2004 Apr 15;22(8):1447–53.
Parente LML, Lino Júnior R de S, Tresvenzol LMF, Vinaud MC, de Paula JR, Paulo NM. Wound Healing and Anti-Inflammatory Effect in Animal Models of Calendula officinalis L. Growing in Brazil. Evidence-Based Complementary and Alternative Medicine. 2012;2012:1–7.
Dinda M, Dasgupta U, Singh N, Bhattacharyya D, Karmakar P. PI3K‐Mediated Proliferation of Fibroblasts by Calendula officinalis Tincture: Implication in Wound Healing. Phytotherapy Research. 2015 Apr 13;29(4):607–16.
Dinda M, Mazumdar S, Das S, Ganguly D, Dasgupta UB, Dutta A, et al. The Water Fraction of Calendula officinalis Hydroethanol Extract Stimulates In Vitro and In Vivo Proliferation of Dermal Fibroblasts in Wound Healing. Phytotherapy Research. 2016 Oct;30(10):1696–707.
Ahmed F, Urooj A. Traditional uses, medicinal properties, and phytopharmacology of Ficus racemosa : A review. Pharm Biol. 2010 Jun 6;48(6):672–81.
Nadeem M, Zeb A. Impact of maturity on phenolic composition and antioxidant activity of medicinally important leaves of Ficus carica L. Physiology and Molecular Biology of Plants. 2018 Sep 30;24(5):881–7.
Salah M, Badr G, Hetta HF, Khalifa WA, Shoreit AA. Fig latex inhibits the growth of pathogenic bacteria invading human diabetic wounds and accelerates wound closure in diabetic mice. Sci Rep. 2022 Dec 17;12(1):21852.
Chopra RN, Chopra IC, Handa KL, Kapur LD. Indigenous drugs of India. . Second Edition. Calcutta: Academic Publishers;, editor. Calcutta: Academic Publishers; 1958. 508–674 p.
Esposito D, Munafo JP, Lucibello T, Baldeon M, Komarnytsky S, Gianfagna TJ. Steroidal glycosides from the bulbs of Easter lily (Lilium longiflorum Thunb.) promote dermal fibroblast migration in vitro. J Ethnopharmacol. 2013 Jul 9;148(2):433–40.
Gao J, Zhang T, Jin ZY, Xu XM, Wang JH, Zha XQ, et al. Structural characterisation, physicochemical properties and antioxidant activity of polysaccharide from Lilium lancifolium Thunb. Food Chem. 2015 Feb;169:430–8.
Zhang T, Gao J, Jin ZY, Xu XM, Chen HQ. Protective effects of polysaccharides from Lilium lancifolium on streptozotocin-induced diabetic mice. Int J Biol Macromol. 2014 Apr 1;65:436–40.
Tetsuto Kanzaki, Nobuhiro Morisaki, Ritsuko Shiina, Yasushi Saito. Role of transforming growth factor-bpathway in the mechanism ofwound healing by saponin from Ginseng Radix rubra. British Journal of Pharmacology . 1998;
Khaheshi I, Keshavarz S, Imani Fooladi AA, Ebrahimi M, Yazdani S, Panahi Y, et al. Loss of expression of TGF-βs and their receptors in chronic skin lesions induced by sulfur mustard as compared with chronic contact dermatitis patients. BMC Dermatol. 2011 Dec 14;11(1):2.
Nassar M, Aboutabl ES, Ahmed R, El-Khrisy ED, Ibrahim K, Sleem A. Secondary metabolites and bioactivities of Myrtus communis. Pharmacognosy Res. 2010;2(6):325.
Ibrahim Tumen Ekaisgemkhkmrap, Hikmet Keles, Markku Reunanen, Andrey Pranovich. Valuation Of The Wound Healing And Anti-Inflammatory Activities And Phytochemical Analysis Of Myrtus Communis L. . Fresenius Environ Bull. 2017;26(7):4420–8.
Khodaie SA, Emadi F, Naseri M, Kamalinejad M, Riahi SM, Alijaniha F, et al. The Effect of Myrtus communis Aqueous Extract-Containing Gel on Wound Healing in Streptozotocin-Induced Diabetic Rats. Curr Drug Discov Technol. 2021 Jul;18(4):542–7.
Haririan Y, Asefnejad A, Hamishehkar H, Farahpour MR. Carboxymethyl chitosan-gelatin-mesoporous silica nanoparticles containing Myrtus communis L. extract as a novel transparent film wound dressing. Int J Biol Macromol. 2023 Sep;127081.
Horinouchi CD da S, Mendes DAGB, Nolte S, Brito PS de, Soley B da S, Favero GM, et al. Anti-proliferative and anti-inflammatory effects of 3β,6β,16β-Trihydroxylup-20(29)-ene on cutaneous inflammation. J Ethnopharmacol. 2017 Jan;195:298–308.
Alaribe FN, Maepa MJ, Mkhumbeni N, Motaung SC. Possible roles of <i>Eucomis autumnalis</i> in bone and cartilage regeneration: A review. Tropical Journal of Pharmaceutical Research. 2018 May 4;17(4):741.
Anaya-Mancipe JM, Queiroz VM, dos Santos RF, Castro RN, Cardoso VS, Vermelho AB, et al. Electrospun Nanofibers Loaded with Plantago major L. Extract for Potential Use in Cutaneous Wound Healing. Pharmaceutics. 2023 Mar 24;15(4):1047.
Atsü MAN, Tosuner MZ, Bilgiç MT. Evaluation of the Effect of Pomegranate Seed Oil on Healing in a Rat Wound Model With Antioxidant, Vascular, and Histopathological Parameters. Int J Low Extrem Wounds. 2021 Aug 31;153473462110405.
Batool Hashemibeni, Maryam Aliakbari, Mohammad Bakhtiari, Mohammad Kazemi, Mohsen Setayeshmehr. The effect of herbal components, pomegranate and icariin on the chondrogenesis of stem cells in the fibrin-micromass hydrogel systemBatool. Journal of Applied Tissue Engineering . 2023;9(1).
Lukiswanto B, Miranti A, Sudjarwo S, Primarizky H, Yuniarti W. Evaluation of wound healing potential of pomegranate (Punica granatum) whole fruit extract on skin burn wound in rats (Rattus norvegicus). J Adv Vet Anim Res. 2019;6(2):202.
Wani TA, Chandrashekara HH, Kumar D, Prasad R, Gopal A, Sardar KK, et al. Wound healing activity of ethanolic extract of Shorea robusta Gaertn. f. resin. Indian J Exp Biol. 2012 Apr;50(4):277–81.
Haririan Y, Asefnejad A, Hamishehkar H, Farahpour MR. Carboxymethyl chitosan-gelatin-mesoporous silica nanoparticles containing Myrtus communis L. extract as a novel transparent film wound dressing. Int J Biol Macromol. 2023 Dec;253:127081.
Raei M, Rajabzadeh G, Zibaei S, Jafari SM, Sani AM. Nano-encapsulation of isolated lactoferrin from camel milk by calcium alginate and evaluation of its release. Int J Biol Macromol. 2015 Aug;79:669–73.
Taib M, Rezzak Y, Bouyazza L, Lyoussi B. Medicinal Uses, Phytochemistry, and Pharmacological Activities of Quercus Species. Evidence-Based Complementary and Alternative Medicine. 2020 Jul 31;2020:1–20.
Sariozlu NY, Kivanc M. Gallnuts (Quercus infectoria Oliv. and Rhus chinensis Mill.) and Their Usage in Health. In: Nuts and Seeds in Health and Disease Prevention. Elsevier; 2011. p. 505–11.
Chokpaisarn J, Chusri S, Amnuaikit T, Udomuksorn W, Voravuthikunchai SP. Potential wound healing activity of Quercus infectoria formulation in diabetic rats. PeerJ. 2017 Jul 24;5:e3608.
Tsioutsiou EE, Cheilari A, Aligiannis N. Ethnopharmacological study of medicinal plants used against skin ailments on Mount Pelion, central Greece. Front Pharmacol. 2023 Jul 31;14.
Medina E, de Castro A, Romero C, Brenes M. Comparison of the Concentrations of Phenolic Compounds in Olive Oils and Other Plant Oils: Correlation with Antimicrobial Activity. J Agric Food Chem. 2006 Jul 1;54(14):4954–61.
Donato‐Trancoso A, V. de Carvalho Faria R, C. de S. Ribeiro B, Nogueira JS, Atella GC, Chen L, et al. Dual effects of extra virgin olive oil in acute wounds. Wound Repair and Regeneration. 2023 May 3;31(3):338–48.
Martin RR, Ghezzo H, Amyot R, Bégin R, Desmeules M, Gauthier JJ, et al. [Quebec spirometry reference values]. Rev Mal Respir. 1998 Dec;15(6):781–8.
Elhage KG, St. Claire K, Daveluy S. Acetic acid and the skin: a review of vinegar in dermatology. Int J Dermatol. 2022 Jul 5;61(7):804–11.
Chen Q, Zhou K. Acetic Acid Use in Chronic Wound Healing. Journal of Wound, Ostomy & Continence Nursing. 2022 May;49(3):286–9.
Use of vinegar (acetic acid) to promote wound healing complicated by hypergranulation tissue. J Am Acad Dermatol. 2009 Mar 1;60(3):AB203.
Imran R, Hassouna T, Sur G, Casey A, Homer V, Barton D, et al. Efficacy and optimal dose of acetic acid to treat colonised burns wounds: protocol for a pilot randomised controlled trial. BMJ Open. 2023 Sep 25;13(9):e058006.
Liu Y, Zhao J, Mu X, Deng J, Wu X, He W, et al. Asiaticoside-nitric oxide promoting diabetic wound healing through the miRNA-21-5p/TGF-β1/SMAD7/TIMP3 signaling pathway. J Ethnopharmacol. 2024 Jan;319:117266.
Kishore B, Siva Prasad M, Murthy GK. Comparison of the dermal wound healing of Centella asiatica extract impregnated collagen and crosslinked collagen scaffolds. . J Chem Pharm Res . 2011;3(3):353–62.
Arribas-López E, Zand N, Ojo O, Snowden MJ, Kochhar T. A Systematic Review of the Effect of Centella asiatica on Wound Healing. Int J Environ Res Public Health. 2022 Mar 10;19(6).
Wan L, Song Z, Wang Z, Dong J, Chen Y, Hu J. Repair effect of centella asiastica (L.) extract on damaged HaCaT cells studied by atomic force microscopy. J Microsc. 2023 Oct 19;
Xiao Y, Chen X, Yin Y, Zheng J, Yi H, Song L. Comparative genetic and epigenetic of the Sphagneticola trilobata (L.) Pruski from different regions in China. BMC Plant Biol. 2023 May 30;23(1):289.
Weng Z, Patel AB, Vasiadi M, Therianou A, Theoharides TC. Luteolin Inhibits Human Keratinocyte Activation and Decreases NF-κB Induction That Is Increased in Psoriatic Skin. PLoS One. 2014 Feb 28;9(2):e90739.
Balekar N, Nakpheng T, Katkam NG, Srichana T. Wound healing activity of ent-kaura-9(11),16-dien-19-oic acid isolated from Wedelia trilobata (L.) leaves. Phytomedicine. 2012 Oct 15;19(13):1178–84.
Flores KE, Quinlan MB. Ethnomedicine of menstruation in rural Dominica, West Indies. J Ethnopharmacol. 2014 May;153(3):624–34.
Balekar N, Katkam NG, Nakpheng T, Jehtae K, Srichana T. Evaluation of the wound healing potential of Wedelia trilobata (L.) leaves. J Ethnopharmacol. 2012 Jun;141(3):817–24.
Wang Z, Xie X, Wang M, Ding M, Gu S, Xing X, et al. Analysis of common and characteristic actions of Panax ginseng and Panax notoginseng in wound healing based on network pharmacology and meta-analysis. J Ginseng Res. 2023 Jul;47(4):493–505.
Men S, Huo Q, Shi L, Yan Y, Yang C, Yu W, et al. Panax notoginseng saponins promotes cutaneous wound healing and suppresses scar formation in mice. J Cosmet Dermatol. 2020 Feb 2;19(2):529–34.
Xiong Y, Chen L, Man J, Hu Y, Cui X. Chemical and bioactive comparison of Panax notoginseng root and rhizome in raw and steamed forms. J Ginseng Res. 2019 Jul;43(3):385–93.
Lee J, Hwang H, Ko EJ, Lee YN, Kwon YM, Kim MC, et al. Immunomodulatory Activity of Red Ginseng against Influenza A Virus Infection. Nutrients. 2014 Jan 27;6(2):517–29.
Nathan S, Nanassy AD, Burkey BA, Davis WJ, Glat PM. The management of paediatric burns with Burns and Wounds ointment and burdock leaves: a case series. J Wound Care. 2020 May 1;29(Sup5a):S30–5.
Pomari E, Stefanon B, Colitti M. Effect of Arctium lappa (burdock) extract on canine dermal fibroblasts. Vet Immunol Immunopathol. 2013 Dec;156(3–4):159–66.
Kolacz NM, Jaroch MT, Bear ML, Hess RF. The Effect of Burns & Wounds (B&W)/Burdock Leaf Therapy on Burn-Injured Amish Patients. Journal of Holistic Nursing. 2014 Dec 25;32(4):327–40.
Schell A, Copp J, Bogie KM, Wetzel R. Honey-Based Salve and Burdock Leaf Dressings as an Alternative to Surgical Debridement of a Traumatic Wound Eschar. Adv Wound Care (New Rochelle). 2019 Mar;8(3):101–7.
G. Pandey, K. Verma, Munna Singh. Evaluation Of Phytochemical, Antibacterial And Free Radical Scavenging Properties Of Azadirachta Indica (Neem) Leaves. Int J Pharm Pharm Sci. 2014;6(2).
Nasrine A, Narayana S, Gulzar Ahmed M, Sultana R, Noushida N, Raunak Salian T, et al. Neem (Azadirachta Indica) and silk fibroin associated hydrogel: Boon for wound healing treatment regimen. Saudi Pharmaceutical Journal. 2023 Oct;31(10):101749.
Viji CS, Trikkurmadom SA, Rajalekshmi G, Pandimadevi M (. Collagen Azadirachta indica (neem) leaves extract hybrid film as a novel wound dressinViji CS, Trikkurmadom SA, Rajalekshmi G, Pandimadevi M (2015) Collagen Azadirachta indica (neem) leaves extract hybrid film as a novel wound dressing: in vitro studies. Int J Pharm Sci Rev Res 32(2):193–199g: in vitro studies. Int J Pharm Sci Rev Res 32(2):193–199. Int J Pharm Sci Rev Res . 2015;32(2):193–9.
Osunwoke Emeka A, Olotu Emamoke J, Allison Theodore A, Onyekwere Julius C. The wound healing effects of aqueous leave extracts of azadirachta indica on wistar rats. Journal of Natural Science and Research. 2013;3(6).
Alzohairy MA. Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment. Evidence-Based Complementary and Alternative Medicine. 2016;2016:1–11.
Motealleh B, Zahedi P, Rezaeian I, Moghimi M, Abdolghaffari AH, Zarandi MA. Morphology, drug release, antibacterial, cell proliferation, and histology studies of chamomile‐loaded wound dressing mats based on electrospun nanofibrous poly(ɛ‐caprolactone)/polystyrene blends. J Biomed Mater Res B Appl Biomater. 2014 Jul 21;102(5):977–87.
Gupta. Chamomile: A herbal medicine of the past with a bright future (Review). Mol Med Rep. 2010 Sep 28;3(6).
Stanojevic LP, Marjanovic-Balaban ZR, Kalaba VD, Stanojevic JS, Cvetkovic DJ. Chemical Composition, Antioxidant and Antimicrobial Activity of Chamomile Flowers Essential Oil ( Matricaria chamomilla L.). Journal of Essential Oil Bearing Plants. 2016 Nov 16;19(8):2017–28.
Rügge SD, Nielsen M, Jacobsen AS, Vang O, Jemec GBE. [Evidence of dermatological effects of chamomile]. Ugeskr Laeger. 2010 Dec 13;172(50):3492–6.
Gupta. Chamomile: A herbal medicine of the past with a bright future (Review). Mol Med Rep. 2010 Sep 28;3(6).
Pazyar N, Yaghoobi R, Rafiee E, Mehrabian A, Feily A. Skin Wound Healing and Phytomedicine: A Review. Skin Pharmacol Physiol. 2014;27(6):303–10.
Niknam S, Tofighi Z, Faramarzi MA, Abdollahifar MA, Sajadi E, Dinarvand R, et al. Polyherbal combination for wound healing: Matricaria chamomilla L. and Punica granatum L. DARU Journal of Pharmaceutical Sciences. 2021 May 9;29(1):133–45.
Garbuio DC, Leite MN, Figueiredo SA, de Freitas LAP, de Carvalho EC, Frade MAC. Topical formulation containing chitosan-chamomile microparticles in cutaneous wound healing in rats. J Wound Care. 2023 Mar 2;32(Sup3a):xxii–xxx.
Ghasemi MR, Ranjbar A, Tamri P, Pourmoslemi S, Nourian A, Dastan D. In vitro Antibacterial Activity and Wound Healing Effects of Achillea millefolium Essential Oil in Rat. J Pharmacopuncture. 2023 Jun 30;26(2):167–74.
Almuhanna Y, Alqasmi MH, AlSudais H, Alrouji M, Kuriri FA, Alissa M, et al. Effect of Achillea fragrantissima Extract on Excision Wound Biofilms of MRSA and Pseudomonas aeruginosa in Diabetic Mice. Int J Mol Sci. 2023 Jun 5;24(11):9774.
Benedek B, Kopp B, Melzig MF. Achillea millefolium L. s.l. – Is the anti-inflammatory activity mediated by protease inhibition? J Ethnopharmacol. 2007 Sep 5;113(2):312–7.
Tadić V, Arsić I, Zvezdanović J, Zugić A, Cvetković D, Pavkov S. The estimation of the traditionally used yarrow ( Achillea millefolium L. Asteraceae) oil extracts with anti-inflamatory potential in topical application. J Ethnopharmacol. 2017 Mar;199:138–48.
Strzępek-Gomółka M, Gaweł-Bęben K, Kukula-Koch W. Achillea Species as Sources of Active Phytochemicals for Dermatological and Cosmetic Applications. Oxid Med Cell Longev. 2021 Mar 25;2021:1–14.
Xue T, Ruan K, Tang Z, Duan J, Xu H. Isolation, structural properties, and bioactivities of polysaccharides from Althaea officinalis Linn.: A review. Int J Biol Macromol. 2023 Jul;242:125098.
Levina LD. [Treatment of hepatic coma in infectious hepatitis]. Klin Med (Mosk). 1974 Jun;52(6):100–3.
Govindarajan R, Vijayakumar M, Pushpangadan P. Antioxidant approach to disease management and the role of ‘Rasayana’ herbs of Ayurveda. J Ethnopharmacol. 2005 Jun;99(2):165–78.
Mohsenikia M, Rafiee S, Rozei LS, Ebrahimi A, Zahmatkesh-Meimandi F, Aref NM, et al. <i>Althaea officinalis</i> improves wound healing in rats: a stereological study. Drug Discov Ther. 2020 Oct 31;14(5):239–42.
Verre J, Boisson M, Paumier A, Tribolo S, Boujedaini N. Anti-inflammatory effects of Arnica montana (mother tincture and homeopathic dilutions) in various cell models. J Ethnopharmacol. 2024 Jan 10;318:117064.
Karow JH, Abt HP, Fröhling M, Ackermann H. Efficacy of Arnica montana D4 for Healing of Wounds After Hallux Valgus Surgery Compared to Diclofenac. The Journal of Alternative and Complementary Medicine. 2008 Jan;14(1):17–25.
Brinkhaus B, Wilkens JM, Lüdtke R, Hunger J, Witt CM, Willich SN. Homeopathic arnica therapy in patients receiving knee surgery: Results of three randomised double-blind trials. Complement Ther Med. 2006 Dec;14(4):237–46.
Marinho BM, Guimarães VHD, Moraes DS, Ribeiro GHM, da Silva RM, Lopes NP, et al. Lychnophora ericoides Mart. (Brazilian arnica) ethanol extract accelerates the skin wound healing process: Evidence for its mechanism of action. Phytomedicine. 2023 Oct;119:155000.
Kaya M, Merdivan M, Tashakkori P, Erdem P, Anderson JL. Analysis of Echinacea flower volatile constituents by HS-SPME-GC/MS using laboratory-prepared and commercial SPME fibers. Journal of Essential Oil Research. 2019 Mar 4;31(2):91–8.
Burlou-Nagy C, Bănică F, Negrean RA, Jurca T, Vicaș LG, Marian E, et al. Determination of the Bioactive Compounds from Echinacea purpurea (L.) Moench Leaves Extracts in Correlation with the Antimicrobial Activity and the In Vitro Wound Healing Potential. Molecules. 2023 Jul 28;28(15):5711.
Bruni R, Brighenti V, Caesar LK, Bertelli D, Cech NB, Pellati F. Analytical methods for the study of bioactive compounds from medicinally used Echinacea species. J Pharm Biomed Anal. 2018 Oct 25;160:443–77.
Karsch-Völk M, Barrett B, Kiefer D, Bauer R, Ardjomand-Woelkart K, Linde K. Echinacea for preventing and treating the common cold. Cochrane Database of Systematic Reviews. 2014 Feb 20;2014(7).
Ciganović P, Jakupović L, Momchev P, Nižić Nodilo L, Hafner A, Zovko Končić M. Extraction Optimization, Antioxidant, Cosmeceutical and Wound Healing Potential of Echinacea purpurea Glycerolic Extracts. Molecules. 2023 Jan 25;28(3).
Velingkar VS, Gupta GL, Hegde NB. A current update on phytochemistry, pharmacology and herb–drug interactions of Hypericum perforatum. Phytochemistry Reviews. 2017 Aug 5;16(4):725–44.
Wölfle U, Seelinger G, Schempp C. Topical Application of St. Johnʼs Wort (Hypericum perforatum). Planta Med. 2013 Nov 8;80(02/03):109–20.
Süntar IP, Akkol EK, Yılmazer D, Baykal T, Kırmızıbekmez H, Alper M, et al. Investigations on the in vivo wound healing potential of Hypericum perforatum L. J Ethnopharmacol. 2010 Feb;127(2):468–77.
Belwal T, Devkota HP, Singh MK, Sharma R, Upadhayay S, Joshi C, et al. St. John’s Wort (Hypericum perforatum). In: Nonvitamin and Nonmineral Nutritional Supplements. Elsevier; 2019. p. 415–32.
Shemesh A, Mayo W.L. Australian tea tree oil: a natural antiseptic and fungicidal agent. . Australian Journal of Pharmacy . 1991;72:802–3.
Shah G, Baghel US. PHARMACOGNOSTIC STANDARDIZATION OF THE LEAF OF MELALEUCA ALTERNIFOLIA (MAIDEN & BETCHE) CHEEL. African Journal of Traditional, Complementary and Alternative Medicines. 2017 Mar 1;14(3):1–11.
Pazyar N, Feily A, Kazerouni A. Green tea in dermatology. Skinmed. 2012;10(6):352–5.
Ahuchaogu AA, Chukwu OJ, Echeme JO. Secondary Metabolites from Mimosa Pudica: Isolation, Purification and NMR Characterization. IOSR Journal of Applied Chemistry. 2017 Mar;10(3):15–20.
Zippel J, Deters A, Hensel A. Arabinogalactans from Mimosa tenuiflora (Willd.) Poiret bark as active principles for wound-healing properties: Specific enhancement of dermal fibroblast activity and minor influence on HaCaT keratinocytes. J Ethnopharmacol. 2009 Jul;124(3):391–6.
Kokane DD, More RY, Kale MB, Nehete MN, Mehendale PC, Gadgoli CH. Evaluation of wound healing activity of root of Mimosa pudica. J Ethnopharmacol. 2009 Jul;124(2):311–5.
Kokane DD, More RY, Kale MB, Nehete MN, Mehendale PC, Gadgoli CH. Evaluation of wound healing activity of root of Mimosa pudica. J Ethnopharmacol. 2009 Jul;124(2):311–5.
El-Mallah MH, El-Shami SM. Investigation of Liquid Wax Components of Egyptian Jojoba Seeds. J Oleo Sci. 2009;58(11):543–8.
Galati G, O’Brien PJ. Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic Biol Med. 2004 Aug 1;37(3):287–303.
Zhang G, Xie F, Sun Y, Yu X, Xiao Z, Fang R, et al. Inhalable Jojoba Oil Dry Nanoemulsion Powders for the Treatment of Lipopolysaccharide- or H2O2-Induced Acute Lung Injury. Pharmaceutics. 2021 Apr 2;13(4):486.
HABASHY R, ABDELNAIM A, KHALIFA A, ALAZIZI M. Anti-inflammatory effects of jojoba liquid wax in experimental models. Pharmacol Res. 2005 Feb;51(2):95–105.
El Sherif F, AlDayel M, Ismail MB, Alrajeh HS, Younis NS, Khattab S. Bio-Stimulant for Improving Simmondsia chinensis Secondary Metabolite Production, as Well as Antimicrobial Activity and Wound Healing Abilities. Plants. 2023 Sep 19;12(18):3311.
HABASHY R, ABDELNAIM A, KHALIFA A, ALAZIZI M. Anti-inflammatory effects of jojoba liquid wax in experimental models. Pharmacol Res. 2005 Feb;51(2):95–105.
de Macedo LM, Santos ÉM dos, Militão L, Tundisi LL, Ataide JA, Souto EB, et al. Rosemary (Rosmarinus officinalis L., syn Salvia rosmarinus Spenn.) and Its Topical Applications: A Review. Plants. 2020 May 21;9(5):651.
Hadizadeh-Talasaz F, Mardani F, Bahri N, Rakhshandeh H, Khajavian N, Taghieh M. Effect of Rosemary Cream on Episiotomy Wound Healing in Primiparous Women: A Randomized Clinical Trial. BMC Complement Med Ther. 2022 Aug 26;22(1):226.
Abu-Al-Basal MA. Healing potential of Rosmarinus officinalis L. on full-thickness excision cutaneous wounds in alloxan-induced-diabetic BALB/c mice. J Ethnopharmacol. 2010 Sep;131(2):443–50.
Khezri K, Farahpour MR, Mounesi Rad S. Accelerated infected wound healing by topical application of encapsulated Rosemary essential oil into nanostructured lipid carriers. Artif Cells Nanomed Biotechnol. 2019 Dec 4;47(1):980–8.
Su X, Xian C, Gao M, Liu G, Wu J. Edible Materials in Tissue Regeneration. Macromol Biosci. 2021 Aug 12;21(8).
Ahn S, Chantre CO, Gannon AR, Lind JU, Campbell PH, Grevesse T, et al. Soy Protein/Cellulose Nanofiber Scaffolds Mimicking Skin Extracellular Matrix for Enhanced Wound Healing. Adv Healthc Mater. 2018 May;7(9):e1701175.
Li F, Liu T, Gu W, Gao Q, Li J, Shi SQ. Bioinspired super-tough and multifunctional soy protein-based material via a facile approach. Chemical Engineering Journal. 2021 Feb 1;405:126700.
Tian H, Guo G, Fu X, Yao Y, Yuan L, Xiang A. Fabrication, properties and applications of soy-protein-based materials: A review. Int J Biol Macromol. 2018 Dec 1;120:475–90.
Jarić S, Kostić O, Mataruga Z, Pavlović D, Pavlović M, Mitrović M, et al. Traditional wound-healing plants used in the Balkan region (Southeast Europe). J Ethnopharmacol. 2018 Jan;211:311–28.
Melnyk N, Popowski D, Strawa JW, Przygodzińska K, Tomczyk M, Piwowarski JP, et al. Skin microbiota metabolism of natural products from comfrey root (Symphytum officinale L.). J Ethnopharmacol. 2024 Jan;318:116968.
Benedek B, Ziegler A, Ottersbach P. Absence of mutagenic effects of a particular Symphytum officinale L. liquid extract in the bacterial reverse mutation assay. Phytotherapy Research. 2010 Mar;24(3):466–8.
Araújo LU, Grabe-Guimarães A, Mosqueira VCF, Carneiro CM, Silva-Barcellos NM. Profile of wound healing process induced by allantoin. Acta Cir Bras. 2010 Oct;25(5):460–1.
Staiger C. Comfrey: A Clinical Overview. Phytotherapy Research. 2012 Oct 23;26(10):1441–8.
Dähnhardt D, Dähnhardt-Pfeiffer S, Groeber-Becker F, Fölster-Holst R, Schmidt M. Epidermal Regeneration Induced by Comfrey Extract: A Study by Light and Electron Microscopy. Skin Pharmacol Physiol. 2020;33(4):189–97.
Chew SK, Teoh WH, Hong SL, Yusoff R. Rutin extraction from female Carica papaya Linn. using ultrasound and microwave-assisted extractive methods: Optimization and extraction efficiencies. Heliyon. 2023 Oct;9(10):e20260.
Mikhalchik E V., Ivanova A V., Anurov M V., Titkova SM, Penkov LYu, Kharaeva ZF, et al. Wound-Healing Effect of Papaya-Based Preparation in Experimental Thermal Trauma. Bull Exp Biol Med. 2004 Jun;137(6):560–2.
Nayak BS, Ramdeen R, Adogwa A, Ramsubhag A, Marshall JR. Wound‐healing potential of an ethanol extract of Carica papaya (Caricaceae) seeds. Int Wound J. 2012 Dec;9(6):650–5.
Varma P, Bhankharia H, Bhatia S. Oats: A Multi-Functional Grain. . J Clin Prev Cardiol . 2016;5:9–17.
Paudel D, Dhungana B, Caffe M, Krishnan P. A Review of Health-Beneficial Properties of Oats. Foods. 2021 Oct 26;10(11):2591.
EL Hosary R, El-Mancy SMS, El Deeb KS, Eid HH, EL Tantawy ME, Shams MM, et al. Efficient wound healing composite hydrogel using Egyptian Avena sativa L. polysaccharide containing β-glucan. Int J Biol Macromol. 2020 Apr;149:1331–8.
Akkol EK, Süntar I, Orhan IE, Keles H, Kan A, Çoksari G. Assessment of dermal wound healing and in vitro antioxidant properties of Avena sativa L. J Cereal Sci. 2011 May;53(3):285–90.
Boisnic S, Branchet MC, Ermosilla V. Healing effect of a spray containing Rhealba oat colloidal extract in an in vitro reconstitution model of skin. Int J Tissue React. 2005;27(3):83–9.
Alhashim M, Lombardo J. Mechanism of Action of Topical Garlic on Wound Healing. Dermatologic Surgery. 2018 May;44(5):630–4.
Ejaz S, Chekarova I, Cho JW, Lee SY, Ashraf S, Lim CW. Effect of aged garlic extract on wound healing: A new frontier in wound management. Drug Chem Toxicol. 2009 Jul 19;32(3):191–203.
Bardaa S, Makni K, Boudaouara O, Bardaa T, Ktari N, Hachicha S, et al. Development and Evaluation of the Wound Healing Effect of a Novel Topical Cream Formula Based on Ginkgo biloba Extract on Wounds in Diabetic Rats. Biomed Res Int. 2021 Oct 13;2021:1–12.
Md S, Abdullah S, Alhakamy NA, Shaik RA, Eldakhakhny BM, Omar UM, et al. Development and Evaluation of Ginkgo biloba/Sodium Alginate Nanocomplex Gel as a Long-Acting Formulation for Wound Healing. Gels. 2022 Mar 19;8(3).
Bairy KL, Ganesh SB, Adiga MS, Shalini A. Impaired wound healing due to cyclophosphamide (CLP) alleviated by supplemental Ginkgo biloba (GB). J Nat Med 2006;6:31-34.
Yang M, Li Z. Development of Green-Synthesized Carbon-Based Nanoparticle for Prevention of Surface Wound Biofilm. Appl Biochem Biotechnol. 2023 Sep 16;
Kaushik S, Kaushik S, Dar L, Yadav JP. Eugenol isolated from supercritical fluid extract of Ocimum sanctum: a potent inhibitor of DENV-2. AMB Express. 2023 Oct 2;13(1):105.
Mittal R, Kumar R, Chahal H. Antimicrobial activity of Ocimum sanctum leaves extracts and oil. Journal of Drug Delivery and Therapeutics. 2018 Nov 15;8(6):201–4.
Goel A, Kumar S, Singh DK, Bhatia AK. Wound healing potential of Ocimum sanctum Linn. with induction of tumor necrosis factor-alpha. Indian J Exp Biol. 2010 Apr;48(4):402–6.
Rachpirom M, Pichayakorn W, Puttarak P. Box-Behnken design to optimize the cross-linked sodium alginate/mucilage/Aloe vera film: Physical and mechanical studies. Int J Biol Macromol. 2023 Aug;246:125568.
Bayrami M, Bayrami A, Habibi‐Yangjeh A, Shafeeyan MS, Feizpoor S, Arvanagh FM, et al. Biologically‐synthesised ZnO/CuO/Ag nanocomposite using propolis extract and coated on the gauze for wound healing applications. IET Nanobiotechnol. 2020 Sep 21;14(7):548–54.
F. N Oguwike, D. P. M. Onubueze. Evaluation of Efficacy of Lemon Juice Extract (Citrius Lemoni Risso) on Wound Healing and Haemostatic Mechanism of Albino Wister Rats. International Journal of Science and Research . 2013;2(9).
Abbasi N, Ghaneialvar H, Moradi R, Zangeneh MM, Zangeneh A. Formulation and characterization of a novel cutaneous wound healing ointment by silver nanoparticles containing Citrus lemon leaf: A chemobiological study. Arabian Journal of Chemistry. 2021 Jul 1;14(7):103246.
Golmakani M, Moayyedi M. Comparison of heat and mass transfer of different microwave‐assisted extraction methods of essential oil from Citrus limon (Lisbon variety) peel. Food Sci Nutr. 2015 Nov 5;3(6):506–18.
Yadav RR, Bhattacharyya A. A 745-year chronology of Cedrus deodara from western Himalaya, . India Dendrochronologia 1992;10:53-61. 1992;10:53–61.
Bisht A, Jain S, Misra A, Dwivedi J, Paliwal S, Sharma S. Cedrus deodara (Roxb. ex D.Don) G.Don: A review of traditional use, phytochemical composition and pharmacology. J Ethnopharmacol. 2021 Oct 28;279:114361.
Rastegari A, Manayi A, Akbarzadeh T, Hojjatifard R, Samadi N, Khanavi M, et al. Cedrus deodara: In Vivo Investigation of Burn Wound Healing Properties. Evidence-Based Complementary and Alternative Medicine. 2023 Apr 7;2023:1–8.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 The Journal of Applied Tissue Engineering
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.