Chitosan: A Brief Review on Structure and Tissue Engineering Application
DOI:
https://doi.org/10.22034/JATE.2014.4Keywords:
Chitosan, Bone tissue engineering, Scaffold, Natural polymer, Skin tissue engineering.Abstract
Tissueengineering is an important therapeutic strategy for present and future medicine. Recently, functional biomaterial researches have been directed towards the development of improved scaffolds for regenerative medicine. Chitosan is a natural polymer from renewable resources, obtained from shell of shellfish, and the wastes of the seafood industry. Many researchers have focused on chitosan as a potential source of bioactive materials in the past few decades. It has novel properties such as biocompatibility, biodegradability, antibacterial, and wound-healing activity. Furthermore, recent studies suggested that chitosan and its derivatives are promising candidates as a supporting material for tissueengineering applications owing to their porous structure, gel forming properties, ease of chemical modification, high affinity to in vivo macromolecules, and so on. In this review, we focus on the skin and bone tissueengineering applications of chitosan.
References
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32. Degim Z, Celebi N, Sayan H, et al. An investigation on skin wound healing in mice with a taurine-chitosan gel formulation. Amino Acids. 2002; 22(2):187–198.
33.Service RF. Tissue engineers build new bone . Science.2000; 289: 1498 –500.
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chitosan/hydroxyapatitenanocomposite rods via in situ hybridization: a potential material as
internal fixation of bone fracture. Biomaterials.2004; 25: 779–785.
36. Teng, S.; Lee, E.; Yoon, B.; Shin, D.; Kim, H.; Oh, J. Chitosan/nanohydroxyapatite composite membranes via dynamic filtration for guided bone regeneration. J. Biomed. Mater. Res. Part A.2009; 88: 569–580.
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38. Zhang, Y.; Venugopal, J.R.; El-Turki, A.; Rama krishna, S.; Su, B.; Lim, C.T. Electrospun
biomimeticnanocompositenanofibers of hydroxyapatite/chitosan for bone tissue engineering.
Biomaterials 2008, 29, 4314–4322.
39. Xianmiao, C.; Yubao, L.; Yi, Z.; Li, Z. ; Jidong, L.; Huanan, W. Properties and in vitro biological evaluation of nano-hydroxyapatite/chitosan membranes for bone guided regeneration. Mater. Sci. Eng. C. 2009; 29: 29–35.
40. Kong, L.; Gao, Y.; Cao, W.; Gong, Y.; Zhao, N.; Zhang, X. Preparation and characterization of nano-hydroxyapatite/chitosan composite scaffolds. J. Biomed. Mater. Res. Part A. 2005; 75A: 275–282.
41. Manjubala, I.; Ponomarev, I.; Wilke, I.; Jandt, K. Growth of osteoblast like cells on biomimetic apatite-coated chitosan scaffolds. J. Biomed. Mater. Res. Part A: Appl. Biomater. 2008; 8: 7–16.
42. Thein-Han, W.; Misra, R. Biomimetic chitosan–nanohydroxyapatite composite scaffolds for bone tissue engineering. ActaBiomater.2009; 5: 1182–1197.
43. Oliveira, J.; Rodrigues, M.; Silv a, S.; Malafaya, P.; Gomes, M.; Viegas, C.; Dias, I.; Azevedo, J.; Mano, J.; Reis, R. Novel hydroxyapatite/chitosan bilayeredscaffold for osteochondral tissue-engineering applications: Scaffold design and its performance when seeded with goat bone marrow stromal cells. Biomaterials.2006 ; 27: 6123–6137.
44. Ding, S. Biodegradation behavior of chitosan/calcium phosphate composites. J. Non-Cryst. Solids .2007; 353: 2367–2373.
45. Yamaguchi, I.; Tokuchi, K.; Fukuzaki, H.; Koyama, Y.; Takakuda, K.; Monma, H.; Tanaka, J. Preparation and microstructure analysis of chitosan/hydroxyapatite nanocomposites. J. Biomed. Mater.Res. 2001; 55: 20–27.
46. Kim, S.-K.; Mendis, E. Bioactive compounds from marine processing byproducts-A review. Food Res. Int. 2006; 39: 383–393.
47. Nath, S.; Dey, A.; Mukhopadhyay, A.K.; Bas u, B. Nanoindentation response of novel
hydroxyapatite-mullite composites. Mater. Sci. Eng. A. 2009; 513–514: 197–201.
2. Isenberg BC, Williams C, Tranquillo RT.“Small-diameter artificial arteries engineered in vitro,” Circ Res. 2006; 98:25
3. Kim BS, Putnam AJ, Kulik TJ, Mooney DJ.Optimizing seeding and culture methods to engineer smooth muscle tissue on biodegradable polymer matrices.BiotechnolBioeng. 1998; 57(1):46
4.Mathieu LM, Mueller TL, Bourban P-E, Pioletti DP, Muller R, Manson J-AE.Architecture and properties of anisotropic polymer composite scaffolds for bone tissue engineering.Biomaterials. 2006; 27:905
5. Dimar JR, Glassman SD.The art of bone graftingCurrOpinOrthopaed. 2007; 18(3):226
6. Mikos AG, Bao Y, Cima LG, Ingber DE, Vacanti JP, Langer R. J Biomed Mater Res. 1993; 27:183
7. Mathieu LM, Mueller TL, Bourban P-E, Pioletti DP, Muller R, Manson J-AE. Biomaterials. 2006; 27:905
8. Shin KC, Kim BS, Kim JH, Park TG, Nam JD, Lee DS.A facile preparation of highly interconnected macroporous PLGA scaffolds by liquid–liquid phase separation II.Polymer. 2005; 46:3801
9. Chung, T.W. et al. Growth of human endothelial cells on different concentrations of Gly-Arg-Gly-Asp grafted chitosan surface. Artificial Organs. 2003; 27 (2), 155-161
10. Araki, Y. and Ito, E. Pathway of chitosan formati on in Mucor-Rouxii - enzymatic deacetylation of chitin. European Journal of Biochemistry. 1975; 55, 71-78
11 Nordtveit, R.J. et al. Degradation of partially N-acetylated chitosans with hen egg white and human lysozyme. Carbohydrate Polymers. 1996; 29 (2), 163-167
12 Lee, K.Y. et al. Blood compatibility and biodegradability of partially N-acylated chitosan derivatives. Biomaterials. 1995; 16 (16), 1211-1216
13. Aiba, S. Studies on chitosan .4. lysozymic hydrolysis of partially N-acetylated chitosans. International Journal of Biological Macromolecules. 1992; 14 (4), 225-228
14. Pangburn, S.H. et al. Lysozyme degradation of partially deacetylated chitin, its films and hydrogels. Biomaterials. 1892; 3 (2), 105-108
15. Tomihata, K. and Ikada, Y. In v itro and in vivo degradation of films of chitin and its deacetylated derivatives.Biomaterials. 1992; 18 (7), 567-575
16. Griffon, D.J. et al. Chitosan scaffolds: Interconnective pore size and cartilage engineering. ActaBiomaterialia. 2006; 2 (3), 313-320.
17. Freyman TM,Yannas IV, Gibson LJ. Cellular aterials asporous scaffolds for tissue engineering.Progr Mater Sci 2001;46:273–82.
18. Seyrek, E. and Dubin, P. Glycosaminoglycans as polyelectrolytes. Advances in Colloid and Interface Science.2010; 158 (1-2), 119-129
19. Hirano, S. Chitin biotechnology applications. Biotechnology Annual Review. 1996; 2, 237-258.
20. Struszczyk, M.H. Chitin and chitosan - Part II. Applications of chitosan.Polimery. 2002; 47 (6), 396-403.
21.Ueno H, Mori T, Fujinaga T. Topical formulations and wound healing applications of chitosan. Adv Drug Deliv Rev. 2001; 52(2):105–115.
22. Boateng JS, Matthews KH, Stevens HN, et al. Wound healing dressings and drug delivery systems: a review. J Pharm Sci. 2008; 97(8):2892–2923.
23. Santos TC, Marques AP, Silva SS, et al. In vitro evaluation of the behaviour of human
polymorphonuclear neutrophils in direct contact with chitosan-based membranes. J Biotechnol.
2007; 132(2):218–226.
24. Ueno H, Murakami M, Okumura M, et al. Chitosan accelerates the production of osteopontin from polymorphonuclear leukocytes. Biomaterials. 2001; 22(12):1667–1673.
25. Ueno H, Yamada H, Tanaka I, et al. Accelerating effects of chitosan for healing at early phase of experimental open wound in dogs. Biomaterials. 1999; 20(15):1407–1414.
26. Peluso G, Petillo O, Ranieri M, et al. Chitosan-mediated stimulation of macrophage function.
Biomaterials. 1994; 15(15):1215–1220.
27. Kojima K, Okamoto Y, Kojima K, et al. Effects of chitin and chitosan on collagen synthesis in wound healing. J Vet Med Sci. 2004; 66(12):1595–1598.
28. Wiegand C, Winter D, Hipler UC. Molecular-weight-dependent toxic effects of chitosans on the human keratinocyte cell line HaCaT. Skin Pharmacol Physiol. 2010; 23(3):164–170.
29. Howling GI, Dettmar PW, Goddard PA, et al. The effect of chitin and chitosan on the proliferation of human skin fibroblasts and keratinocytes in vitro.Biomaterials. 2001; 22(22):2959–2966.
30. Nascimento EG, Sampaio TB, Medeiros AC, et al. Evaluation of chitosan gel with 1% silversulfadiazine as an alternative for burn wound treatment in rats. Acta Cir Bras. 2009; 24(6):460–465.
31. Klokkevold PR, Vandemark L, Kenney EB, et al. Osteogenesis enhanced by chitosan (poly-N-acetyl glucosaminoglycan) in vitro. J Periodontol. 1996; 67(11):1170–1175.
32. Degim Z, Celebi N, Sayan H, et al. An investigation on skin wound healing in mice with a taurine-chitosan gel formulation. Amino Acids. 2002; 22(2):187–198.
33.Service RF. Tissue engineers build new bone . Science.2000; 289: 1498 –500.
34. Di Martino, A.; Sittinger, M.; Risbud, M.V. Chitosan: A versatile biopolymer for orthopaedic
tissue-engineering. Biomaterials.2005; 26:5983–5990.
35. Hu, Q.; Li, B.; Wang, M.; Shen, J. Preparat ion and characterization of biodegradable
chitosan/hydroxyapatitenanocomposite rods via in situ hybridization: a potential material as
internal fixation of bone fracture. Biomaterials.2004; 25: 779–785.
36. Teng, S.; Lee, E.; Yoon, B.; Shin, D.; Kim, H.; Oh, J. Chitosan/nanohydroxyapatite composite membranes via dynamic filtration for guided bone regeneration. J. Biomed. Mater. Res. Part A.2009; 88: 569–580.
37. Chen, F.; Wang, Z.; Lin, C. Preparation and characterization of nano sized hydroxyapatite particles and hydroxyapatite/chitosan nano-composite for use in biomedical materials. Mater.Lett. 2002, 57 , 858–861.
38. Zhang, Y.; Venugopal, J.R.; El-Turki, A.; Rama krishna, S.; Su, B.; Lim, C.T. Electrospun
biomimeticnanocompositenanofibers of hydroxyapatite/chitosan for bone tissue engineering.
Biomaterials 2008, 29, 4314–4322.
39. Xianmiao, C.; Yubao, L.; Yi, Z.; Li, Z. ; Jidong, L.; Huanan, W. Properties and in vitro biological evaluation of nano-hydroxyapatite/chitosan membranes for bone guided regeneration. Mater. Sci. Eng. C. 2009; 29: 29–35.
40. Kong, L.; Gao, Y.; Cao, W.; Gong, Y.; Zhao, N.; Zhang, X. Preparation and characterization of nano-hydroxyapatite/chitosan composite scaffolds. J. Biomed. Mater. Res. Part A. 2005; 75A: 275–282.
41. Manjubala, I.; Ponomarev, I.; Wilke, I.; Jandt, K. Growth of osteoblast like cells on biomimetic apatite-coated chitosan scaffolds. J. Biomed. Mater. Res. Part A: Appl. Biomater. 2008; 8: 7–16.
42. Thein-Han, W.; Misra, R. Biomimetic chitosan–nanohydroxyapatite composite scaffolds for bone tissue engineering. ActaBiomater.2009; 5: 1182–1197.
43. Oliveira, J.; Rodrigues, M.; Silv a, S.; Malafaya, P.; Gomes, M.; Viegas, C.; Dias, I.; Azevedo, J.; Mano, J.; Reis, R. Novel hydroxyapatite/chitosan bilayeredscaffold for osteochondral tissue-engineering applications: Scaffold design and its performance when seeded with goat bone marrow stromal cells. Biomaterials.2006 ; 27: 6123–6137.
44. Ding, S. Biodegradation behavior of chitosan/calcium phosphate composites. J. Non-Cryst. Solids .2007; 353: 2367–2373.
45. Yamaguchi, I.; Tokuchi, K.; Fukuzaki, H.; Koyama, Y.; Takakuda, K.; Monma, H.; Tanaka, J. Preparation and microstructure analysis of chitosan/hydroxyapatite nanocomposites. J. Biomed. Mater.Res. 2001; 55: 20–27.
46. Kim, S.-K.; Mendis, E. Bioactive compounds from marine processing byproducts-A review. Food Res. Int. 2006; 39: 383–393.
47. Nath, S.; Dey, A.; Mukhopadhyay, A.K.; Bas u, B. Nanoindentation response of novel
hydroxyapatite-mullite composites. Mater. Sci. Eng. A. 2009; 513–514: 197–201.
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Published
2019-12-04
How to Cite
Jamalpoor , Z. (2019). Chitosan: A Brief Review on Structure and Tissue Engineering Application. The Journal of Applied Tissue Engineering, 1(1), 3–6. https://doi.org/10.22034/JATE.2014.4
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