Role of Tissue Scaffolds in Skin Wound Healing: A Systematic Review
DOI:
https://doi.org/10.22034/JATE.2015.10Keywords:
Tissue Scaffolds; Traumatic Wound Healing; Skin; Nursing; bio-engineering; Systematic ReviewAbstract
Researchers have evaluated the biological and synthetic scaffolds to create a similar replacement tissue that is suitable for repairf human skin wounds. In this review we examine the wound healing role of these tissue scaffolds in recent articles. In this study we search multiple medical databases (Pub Med, Science Direct, and ProQuest) with Cochrane guideline and limit the search to “systematic review” for identifying the role of various tissue scaffolds in the wound healing process. We apply these major sources of data without any limitation in terms of study designs. A total of 3254 different articles that are published over the last five years were located through the search, of which 33 met inclusion criteria. Twenty three of these were identified through Science Direct, five from Pub Med and five from Pro Quest. We find various research designs in this study such as case-control, comparative, in vitro scaffold testing and review articles. Research finding that show new scaffolds with various wound healing properties concomitant with application of different growth factors or stem cell seeding. In this article, searching the databases is the most effective means of ensuring that all relevant papers are included in the systematic review. Next step in this research includes further human research about healing effects of proper and biologically tested tissue scaffolds in real patients.
References
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10. Sai K P, Babu M. Collagen based dressings—a review. Burns. 2000;26(1):54-62.
11. Cornelius VJ, Majcen N, Snowden MJ, Mitchell JC, Voncina B, editors. Preparation of SMART wound dressings based on colloidal microgels and textile fibres. Smart Materials, Nano-and Micro-Smart Systems; 2006: International Society for Optics and Photonics.
12. Boateng JS, Matthews KH, Stevens HN, Eccleston GM. Wound healing dressings and drug delivery systems: a review. Journal of pharmaceutical sciences. 2008;97(8):2892-923.
13. Chung HJ, Park TG. Surface engineered and drug releasing pre-fabricated scaffolds for tissue engineering. Advanced drug delivery reviews. 2007;59(4):249-62.
14. Garg T, Singh O, Arora S, Murthy R. Scaffold: a novel carrier for cell and drug delivery. Critical Reviews™ in Therapeutic Drug Carrier Systems. 2012;29(1).
15. Kumbar S, Nukavarapu S, James R, Nair L, Laurencin C. Electrospun poly (lactic acid-co-glycolic acid) scaffolds for skin tissue engineering. Biomaterials. 2008;29(30):4100.
16. Agrawal C, Ray RB. Biodegradable polymeric scaffolds for musculoskeletal tissue engineering. Journal of Biomedical Materials Research. 2001;55(2):141-50.
17. Wong VW, Rustad KC, Galvez MG, Neofytou E, Glotzbach JP, Januszyk M, et al. Engineered pullulan–collagen composite dermal hydrogels improve early cutaneous wound healing. Tissue Engineering Part A. 2010;17(5-6):631-44.
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19. Ninan N, Muthiah M, Bt Yahaya NA, Park I-K, Elain A, Wong TW, et al. Antibacterial and wound healing analysis of gelatin/zeolite scaffolds. Colloids and Surfaces B: Biointerfaces. 2014;115:244-52.
20. Soller EC, Tzeranis DS, Miu K, So PT, Yannas IV. Common features of optimal collagen scaffolds that disrupt wound contraction and enhance regeneration both in peripheral nerves and in skin. Biomaterials. 2012;33(19):4783-91.
21. Xie Z, Paras CB, Weng H, Punnakitikashem P, Su L-C, Vu K, et al. Dual growth factor releasing multi-functional nanofibers for wound healing. Acta biomaterialia. 2013;9(12):9351-9.
22. Matsumoto Y, Ikeda K, Yamaya Y, Yamashita K, Saito T, Hoshino Y, et al. The usefulness of the collagen and elastin sponge derived from salmon as an artificial dermis and scaffold for tissue engineerin. Biomedical Research. 2011;32(1):29-36.
23. Zajicek R, Mandys V, Mestak O, Sevcik J, Königova R, Matouskova E. Human keratinocyte growth and differentiation on acellular porcine dermal matrix in relation to wound healing potential. The Scientific World Journal. 2012;2012.
24. Shichu X, Shihui Z, Hengyu L, Jun Y, Kaiyang L, Zhaofan X. Feasibility study of composite skin reconstructed by mixing keratinocytes and acellular dermal matrix for wound repair. Swiss medical weekly. 2009;139(1):16.
25. Duan H, Feng B, Guo X, Wang J, Zhao L, Zhou G, et al. Engineering of epidermis skin grafts using electrospun nanofibrous gelatin/polycaprolactone membranes. International journal of nanomedicine. 2013;8:2077.
26. Huang W-Y, Yeh C-L, Lin J-H, Yang J-S, Ko T-H, Lin Y-H. Development of fibroblast culture in three-dimensional activated carbon fiber-based scaffold for wound healing. Journal of Materials Science: Materials in Medicine. 2012;23(6):1465-78.
27. Dubský M, Kubinová Š, Širc J, Voska L, Zajíček R, Zajícová A, et al. Nanofibers prepared by needleless electrospinning technology as scaffolds for wound healing. Journal of Materials Science: Materials in Medicine. 2012;23(4):931-41.
28. Ghosh Auddy R, Abdullah MF, Das S, Roy P, Datta S, Mukherjee A. New Guar Biopolymer Silver Nanocomposites for Wound Healing Applications. BioMed research international. 2013;2013.
29. Schneider A, Garlick JA, Egles C. Self-assembling peptide nanofiber scaffolds accelerate wound healing. PloS one. 2008;3(1):e1410.
30. Zhang X, Deng Z, Wang H, Yang Z, Guo W, Li Y, et al. Expansion and delivery of human fibroblasts on micronized acellular dermal matrix for skin regeneration. Biomaterials. 2009;30(14):2666-74.
31. Losi P, Briganti E, Errico C, Lisella A, Sanguinetti E, Chiellini F, et al. Fibrin-based scaffold incorporating VEGF-and bFGF-loaded nanoparticles stimulates wound healing in diabetic mice. Acta biomaterialia. 2013;9(8):7814-21.
32. Yang C, Xu L, Zhou Y, Zhang X, Huang X, Wang M, et al. A green fabrication approach of gelatin/CM-chitosan hybrid hydrogel for wound healing. Carbohydrate Polymers. 2010;82(4):1297-305.
33. Chen S-H, Chang Y, Lee K-R, Lai J-Y. A three-dimensional dual-layer nano/microfibrous structure of electrospun chitosan/poly (d, l-lactide) membrane for the improvement of cytocompatibility. Journal of Membrane Science. 2014;450:224-34.
34. Judith R, Nithya M, Rose C, Mandal AB. Biopolymer gel matrix as acellular scaffold for enhanced dermal tissue regeneration. Biologicals. 2012;40(4):231-9.
35. Muzzarelli RA. Chitins and chitosans for the repair of wounded skin, nerve, cartilage and bone. Carbohydrate Polymers. 2009;76(2):167-82.
36. Kim I-Y, Seo S-J, Moon H-S, Yoo M-K, Park I-Y, Kim B-C, et al. Chitosan and its derivatives for tissue engineering applications. Biotechnology advances. 2008;26(1):1-21.
37. Jin G, Prabhakaran MP, Kai D, Ramakrishna S. Controlled release of multiple epidermal induction factors through core–shell nanofibers for skin regeneration. European Journal of Pharmaceutics and Biopharmaceutics. 2013;85(3):689-98.
38. Steffens D, Leonardi D, Soster PRdL, Lersch M, Rosa A, Crestani T, et al. Development of a new nanofiber scaffold for use with stem cells in a third degree burn animal model. Burns. 2014.
39. Kontogiannopoulos KN, Assimopoulou AN, Tsivintzelis I, Panayiotou C, Papageorgiou VP. Electrospun fiber mats containing shikonin and derivatives with potential biomedical applications. International journal of pharmaceutics. 2011;409(1):216-28.
40. Mohiti-Asli M, Pourdeyhimi B, Loboa EG. Novel, silver-ion-releasing nanofibrous scaffolds exhibit excellent antibacterial efficacy without the use of silver nanoparticles. Acta biomaterialia. 2014;10(5):2096-104.
41. Yang Y, Xia T, Zhi W, Wei L, Weng J, Zhang C, et al. Promotion of skin regeneration in diabetic rats by electrospun core-sheath fibers loaded with basic fibroblast growth factor. Biomaterials. 2011;32(18):4243-54.
42. Kundu B, Kundu S. Silk sericin/polyacrylamide in situ forming hydrogels for dermal reconstruction. Biomaterials. 2012;33(30):7456.
43. Kurpinski KT, Stephenson JT, Janairo RRR, Lee H, Li S. The effect of fiber alignment and heparin coating on cell infiltration into nanofibrous PLLA scaffolds. Biomaterials. 2010;31(13):3536-42.
44. Guo R, Xu S, Ma L, Huang A, Gao C. The healing of full-thickness burns treated by using plasmid DNA encoding VEGF-165 activated collagen–chitosan dermal equivalents. Biomaterials. 2011;32(4):1019-31.
45. Salem H, Ciba P, Rapoport D, Egana J, Reithmayer K, Kadry M, et al. The influence of pancreas-derived stem cells on scaffold based skin regeneration. Biomaterials. 2009;30(5):789-96.
46. Wang X, You C, Hu X, Zheng Y, Li Q, Feng Z, et al. The roles of knitted mesh-reinforced collagen–chitosan hybrid scaffold in the one-step repair of full-thickness skin defects in rats. Acta biomaterialia. 2013;9(8):7822-32.
47. Jin G, Prabhakaran MP, Kai D, Annamalai SK, Arunachalam KD, Ramakrishna S. Tissue engineered plant extracts as nanofibrous wound dressing. Biomaterials. 2013;34(3):724-34.
48. Loo Y, Wong Y-C, Cai EZ, Ang C-H, Raju A, Lakshmanan A, et al. Ultrashort peptide nanofibrous hydrogels for the acceleration of healing of burn wounds. Biomaterials. 2014;35(17):4805-14.
49. Sun X, Cheng L, Zhu W, Hu C, Jin R, Sun B, et al. Use of ginsenoside Rg3-loaded electrospun PLGA fibrous membranes as wound cover induces healing and inhibits hypertrophic scar formation of the skin. Colloids and Surfaces B: Biointerfaces. 2014;115:61-70.
50. Wang H-M, Chou Y-T, Wen Z-H, Wang Z-R, Chen C-H, Ho M-L. Novel biodegradable porous scaffold applied to skin regeneration. PloS one. 2013;8(6):e56330.
51. Murphy G, Orgill D, Yannas I. Partial dermal regeneration is induced by biodegradable collagen-glycosaminoglycan grafts. Laboratory investigation; a journal of technical methods and pathology. 1990;62(3):305-13.
52. Dreesmann L, Ahlers M, Schlosshauer B. The pro-angiogenic characteristics of a cross-linked gelatin matrix. Biomaterials. 2007;28(36):5536-43.
53. Mohiti-Asli M, Pourdeyhimi B, Loboa EG. Novel, silver-ion-releasing nanofibrous scaffolds exhibit excellent antibacterial efficacy without the use of silver nanoparticles. Acta biomaterialia. 2013.
2. Boyce ST, Warden GD. Principles and practices for treatment of cutaneous wounds with cultured skin substitutes. The American journal of surgery. 2002;183(4):445-56.
3. Stiefel D, Schiestl C, Meuli M. Integra Artificial Skin® for burn scar revision in adolescents and children. Burns. 2010;36(1):114-20.
4. Singer AJ, Clark R. Cutaneous wound healing. N Engl J Med. 1999;341(10):738-46.
5. Adamian A, Dobysh S, Kilimchuk L, Shandurenko I, Chekmareva I. Development of new biologically active dressings and methodology of their use]. Khirurgiia. 2004 (12):10.
6. Lodish H. Molecular cell biology: Macmillan; 2008.
7. Guo S, DiPietro LA. Factors affecting wound healing. Journal of dental research. 2010;89(3):219-29.
8. De la Torre J, Sholar A. Wound healing: Chronic wounds. Emedicine com Accessed January. 2006;20:2008.
9. Kudi A, Umoh J, Eduvie L, Gefu J. Screening of some Nigerian medicinal plants for antibacterial activity. Journal of Ethnopharmacology. 1999;67(2):225-8.
10. Sai K P, Babu M. Collagen based dressings—a review. Burns. 2000;26(1):54-62.
11. Cornelius VJ, Majcen N, Snowden MJ, Mitchell JC, Voncina B, editors. Preparation of SMART wound dressings based on colloidal microgels and textile fibres. Smart Materials, Nano-and Micro-Smart Systems; 2006: International Society for Optics and Photonics.
12. Boateng JS, Matthews KH, Stevens HN, Eccleston GM. Wound healing dressings and drug delivery systems: a review. Journal of pharmaceutical sciences. 2008;97(8):2892-923.
13. Chung HJ, Park TG. Surface engineered and drug releasing pre-fabricated scaffolds for tissue engineering. Advanced drug delivery reviews. 2007;59(4):249-62.
14. Garg T, Singh O, Arora S, Murthy R. Scaffold: a novel carrier for cell and drug delivery. Critical Reviews™ in Therapeutic Drug Carrier Systems. 2012;29(1).
15. Kumbar S, Nukavarapu S, James R, Nair L, Laurencin C. Electrospun poly (lactic acid-co-glycolic acid) scaffolds for skin tissue engineering. Biomaterials. 2008;29(30):4100.
16. Agrawal C, Ray RB. Biodegradable polymeric scaffolds for musculoskeletal tissue engineering. Journal of Biomedical Materials Research. 2001;55(2):141-50.
17. Wong VW, Rustad KC, Galvez MG, Neofytou E, Glotzbach JP, Januszyk M, et al. Engineered pullulan–collagen composite dermal hydrogels improve early cutaneous wound healing. Tissue Engineering Part A. 2010;17(5-6):631-44.
18. Williams DF. Definitions in Biomaterials: Proceedings of a Consensus Conference of the European Society for Biomaterials, Chester, Engl., March 3-5, 1986: Elsevier; 1987.
19. Ninan N, Muthiah M, Bt Yahaya NA, Park I-K, Elain A, Wong TW, et al. Antibacterial and wound healing analysis of gelatin/zeolite scaffolds. Colloids and Surfaces B: Biointerfaces. 2014;115:244-52.
20. Soller EC, Tzeranis DS, Miu K, So PT, Yannas IV. Common features of optimal collagen scaffolds that disrupt wound contraction and enhance regeneration both in peripheral nerves and in skin. Biomaterials. 2012;33(19):4783-91.
21. Xie Z, Paras CB, Weng H, Punnakitikashem P, Su L-C, Vu K, et al. Dual growth factor releasing multi-functional nanofibers for wound healing. Acta biomaterialia. 2013;9(12):9351-9.
22. Matsumoto Y, Ikeda K, Yamaya Y, Yamashita K, Saito T, Hoshino Y, et al. The usefulness of the collagen and elastin sponge derived from salmon as an artificial dermis and scaffold for tissue engineerin. Biomedical Research. 2011;32(1):29-36.
23. Zajicek R, Mandys V, Mestak O, Sevcik J, Königova R, Matouskova E. Human keratinocyte growth and differentiation on acellular porcine dermal matrix in relation to wound healing potential. The Scientific World Journal. 2012;2012.
24. Shichu X, Shihui Z, Hengyu L, Jun Y, Kaiyang L, Zhaofan X. Feasibility study of composite skin reconstructed by mixing keratinocytes and acellular dermal matrix for wound repair. Swiss medical weekly. 2009;139(1):16.
25. Duan H, Feng B, Guo X, Wang J, Zhao L, Zhou G, et al. Engineering of epidermis skin grafts using electrospun nanofibrous gelatin/polycaprolactone membranes. International journal of nanomedicine. 2013;8:2077.
26. Huang W-Y, Yeh C-L, Lin J-H, Yang J-S, Ko T-H, Lin Y-H. Development of fibroblast culture in three-dimensional activated carbon fiber-based scaffold for wound healing. Journal of Materials Science: Materials in Medicine. 2012;23(6):1465-78.
27. Dubský M, Kubinová Š, Širc J, Voska L, Zajíček R, Zajícová A, et al. Nanofibers prepared by needleless electrospinning technology as scaffolds for wound healing. Journal of Materials Science: Materials in Medicine. 2012;23(4):931-41.
28. Ghosh Auddy R, Abdullah MF, Das S, Roy P, Datta S, Mukherjee A. New Guar Biopolymer Silver Nanocomposites for Wound Healing Applications. BioMed research international. 2013;2013.
29. Schneider A, Garlick JA, Egles C. Self-assembling peptide nanofiber scaffolds accelerate wound healing. PloS one. 2008;3(1):e1410.
30. Zhang X, Deng Z, Wang H, Yang Z, Guo W, Li Y, et al. Expansion and delivery of human fibroblasts on micronized acellular dermal matrix for skin regeneration. Biomaterials. 2009;30(14):2666-74.
31. Losi P, Briganti E, Errico C, Lisella A, Sanguinetti E, Chiellini F, et al. Fibrin-based scaffold incorporating VEGF-and bFGF-loaded nanoparticles stimulates wound healing in diabetic mice. Acta biomaterialia. 2013;9(8):7814-21.
32. Yang C, Xu L, Zhou Y, Zhang X, Huang X, Wang M, et al. A green fabrication approach of gelatin/CM-chitosan hybrid hydrogel for wound healing. Carbohydrate Polymers. 2010;82(4):1297-305.
33. Chen S-H, Chang Y, Lee K-R, Lai J-Y. A three-dimensional dual-layer nano/microfibrous structure of electrospun chitosan/poly (d, l-lactide) membrane for the improvement of cytocompatibility. Journal of Membrane Science. 2014;450:224-34.
34. Judith R, Nithya M, Rose C, Mandal AB. Biopolymer gel matrix as acellular scaffold for enhanced dermal tissue regeneration. Biologicals. 2012;40(4):231-9.
35. Muzzarelli RA. Chitins and chitosans for the repair of wounded skin, nerve, cartilage and bone. Carbohydrate Polymers. 2009;76(2):167-82.
36. Kim I-Y, Seo S-J, Moon H-S, Yoo M-K, Park I-Y, Kim B-C, et al. Chitosan and its derivatives for tissue engineering applications. Biotechnology advances. 2008;26(1):1-21.
37. Jin G, Prabhakaran MP, Kai D, Ramakrishna S. Controlled release of multiple epidermal induction factors through core–shell nanofibers for skin regeneration. European Journal of Pharmaceutics and Biopharmaceutics. 2013;85(3):689-98.
38. Steffens D, Leonardi D, Soster PRdL, Lersch M, Rosa A, Crestani T, et al. Development of a new nanofiber scaffold for use with stem cells in a third degree burn animal model. Burns. 2014.
39. Kontogiannopoulos KN, Assimopoulou AN, Tsivintzelis I, Panayiotou C, Papageorgiou VP. Electrospun fiber mats containing shikonin and derivatives with potential biomedical applications. International journal of pharmaceutics. 2011;409(1):216-28.
40. Mohiti-Asli M, Pourdeyhimi B, Loboa EG. Novel, silver-ion-releasing nanofibrous scaffolds exhibit excellent antibacterial efficacy without the use of silver nanoparticles. Acta biomaterialia. 2014;10(5):2096-104.
41. Yang Y, Xia T, Zhi W, Wei L, Weng J, Zhang C, et al. Promotion of skin regeneration in diabetic rats by electrospun core-sheath fibers loaded with basic fibroblast growth factor. Biomaterials. 2011;32(18):4243-54.
42. Kundu B, Kundu S. Silk sericin/polyacrylamide in situ forming hydrogels for dermal reconstruction. Biomaterials. 2012;33(30):7456.
43. Kurpinski KT, Stephenson JT, Janairo RRR, Lee H, Li S. The effect of fiber alignment and heparin coating on cell infiltration into nanofibrous PLLA scaffolds. Biomaterials. 2010;31(13):3536-42.
44. Guo R, Xu S, Ma L, Huang A, Gao C. The healing of full-thickness burns treated by using plasmid DNA encoding VEGF-165 activated collagen–chitosan dermal equivalents. Biomaterials. 2011;32(4):1019-31.
45. Salem H, Ciba P, Rapoport D, Egana J, Reithmayer K, Kadry M, et al. The influence of pancreas-derived stem cells on scaffold based skin regeneration. Biomaterials. 2009;30(5):789-96.
46. Wang X, You C, Hu X, Zheng Y, Li Q, Feng Z, et al. The roles of knitted mesh-reinforced collagen–chitosan hybrid scaffold in the one-step repair of full-thickness skin defects in rats. Acta biomaterialia. 2013;9(8):7822-32.
47. Jin G, Prabhakaran MP, Kai D, Annamalai SK, Arunachalam KD, Ramakrishna S. Tissue engineered plant extracts as nanofibrous wound dressing. Biomaterials. 2013;34(3):724-34.
48. Loo Y, Wong Y-C, Cai EZ, Ang C-H, Raju A, Lakshmanan A, et al. Ultrashort peptide nanofibrous hydrogels for the acceleration of healing of burn wounds. Biomaterials. 2014;35(17):4805-14.
49. Sun X, Cheng L, Zhu W, Hu C, Jin R, Sun B, et al. Use of ginsenoside Rg3-loaded electrospun PLGA fibrous membranes as wound cover induces healing and inhibits hypertrophic scar formation of the skin. Colloids and Surfaces B: Biointerfaces. 2014;115:61-70.
50. Wang H-M, Chou Y-T, Wen Z-H, Wang Z-R, Chen C-H, Ho M-L. Novel biodegradable porous scaffold applied to skin regeneration. PloS one. 2013;8(6):e56330.
51. Murphy G, Orgill D, Yannas I. Partial dermal regeneration is induced by biodegradable collagen-glycosaminoglycan grafts. Laboratory investigation; a journal of technical methods and pathology. 1990;62(3):305-13.
52. Dreesmann L, Ahlers M, Schlosshauer B. The pro-angiogenic characteristics of a cross-linked gelatin matrix. Biomaterials. 2007;28(36):5536-43.
53. Mohiti-Asli M, Pourdeyhimi B, Loboa EG. Novel, silver-ion-releasing nanofibrous scaffolds exhibit excellent antibacterial efficacy without the use of silver nanoparticles. Acta biomaterialia. 2013.
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Published
2019-12-05
How to Cite
Mansourzadeh, A. R. ., Najafi Mehri, S. ., & Nourani, M. R. (2019). Role of Tissue Scaffolds in Skin Wound Healing: A Systematic Review. The Journal of Applied Tissue Engineering, 2(1), 1–12. https://doi.org/10.22034/JATE.2015.10
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